Detailed information of TA system TA216307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 2058580..2059127
• Replicon: chromosome
• Accession: NZ_CP083361
• Organism: Vibrio parahaemolyticus strain 20-082E4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K9N54_RS09560
• Protein ID: WP_025793438.1
• Coordinates: 2058580..2058882 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U3A269
• Locus tag: K9N54_RS09565
• Protein ID: WP_005448240.1
• Coordinates: 2058870..2059127 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9N54_RS09500 (K9N54_09480)	2053675..2053767	-	93	WP_079882702.1	DUF3265 domain-containing protein	-
K9N54_RS09505 (K9N54_09485)	2053789..2054514	-	726	WP_025793457.1	class I SAM-dependent methyltransferase	-
K9N54_RS09510 (K9N54_09490)	2054656..2055033	-	378	WP_156216529.1	hypothetical protein	-
K9N54_RS09515	2055126..2055215	-	90	WP_072832911.1	DUF3265 domain-containing protein	-
K9N54_RS09520 (K9N54_09500)	2055674..2055766	-	93	WP_078235736.1	DUF3265 domain-containing protein	-
K9N54_RS09525 (K9N54_09505)	2055792..2056034	-	243	WP_080765108.1	zinc ribbon domain-containing protein	-
K9N54_RS09530 (K9N54_09510)	2056283..2056588	-	306	WP_021453216.1	hypothetical protein	-
K9N54_RS09535 (K9N54_09515)	2056620..2056730	-	111	WP_082798391.1	DUF3265 domain-containing protein	-
K9N54_RS09540 (K9N54_09520)	2056738..2057022	-	285	WP_017448465.1	MazG nucleotide pyrophosphohydrolase domain-containing protein	-
K9N54_RS09545 (K9N54_09525)	2057067..2057159	-	93	WP_005494856.1	DUF3265 domain-containing protein	-
K9N54_RS09550 (K9N54_09530)	2057174..2057725	-	552	WP_224067025.1	hypothetical protein	-
K9N54_RS09555 (K9N54_09535)	2057868..2058413	-	546	WP_025793483.1	hypothetical protein	-
K9N54_RS09560 (K9N54_09540)	2058580..2058882	-	303	WP_025793438.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K9N54_RS09565 (K9N54_09545)	2058870..2059127	-	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K9N54_RS09570 (K9N54_09550)	2059287..2059760	-	474	WP_025534629.1	hypothetical protein	-
K9N54_RS09575 (K9N54_09555)	2059788..2059916	-	129	WP_080277532.1	DUF3265 domain-containing protein	-
K9N54_RS09580 (K9N54_09560)	2060359..2060451	-	93	WP_080259420.1	DUF3265 domain-containing protein	-
K9N54_RS09585 (K9N54_09565)	2060477..2061082	-	606	WP_140142847.1	hypothetical protein	-
K9N54_RS09590 (K9N54_09570)	2061131..2061220	-	90	WP_074190212.1	DUF3265 domain-containing protein	-
K9N54_RS09595 (K9N54_09575)	2061854..2062228	-	375	WP_025793490.1	hypothetical protein	-
K9N54_RS09600 (K9N54_09580)	2062254..2062346	-	93	WP_072606053.1	DUF3265 domain-containing protein	-
K9N54_RS09605 (K9N54_09585)	2062372..2062719	-	348	WP_025793492.1	zinc ribbon domain-containing protein	-
K9N54_RS09610 (K9N54_09590)	2062836..2063216	-	381	WP_104411071.1	hypothetical protein	-
K9N54_RS09615 (K9N54_09595)	2063244..2063336	-	93	WP_005494820.1	DUF3265 domain-containing protein	-
K9N54_RS09620 (K9N54_09600)	2063806..2063898	-	93	WP_072612521.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2041179..2166543	125364
	-	inside	Integron	-	-	2043131..2087443	44312

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11536.51 Da
• Isoelectric Point: 5.8623

>T216307 WP_025793438.1 NZ_CP083361:c2058882-2058580 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQAIFSKVERLVAFPESGRIPPELAHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Nucleotide

• Length: 303 bp

>T216307 NZ_CP113007:c2448488-2448195 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9606.10 Da
• Isoelectric Point: 6.7269

>AT216307 WP_005448240.1 NZ_CP083361:c2059127-2058870 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Nucleotide

• Length: 258 bp

>AT216307 NZ_CP113007:c2448700-2448491 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A432DGX8