Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 2046893..2047438 | Replicon | chromosome |
| Accession | NZ_CP083361 | ||
| Organism | Vibrio parahaemolyticus strain 20-082E4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | K9N54_RS09440 | Protein ID | WP_025793277.1 |
| Coordinates | 2047142..2047438 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q7MKD6 |
| Locus tag | K9N54_RS09435 | Protein ID | WP_000557294.1 |
| Coordinates | 2046893..2047135 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9N54_RS09410 (K9N54_09400) | 2042993..2043427 | - | 435 | Protein_1825 | GNAT family N-acetyltransferase | - |
| K9N54_RS09415 (K9N54_09405) | 2043606..2044016 | - | 411 | WP_024701711.1 | hypothetical protein | - |
| K9N54_RS09420 (K9N54_09410) | 2044097..2044987 | - | 891 | WP_005485669.1 | hypothetical protein | - |
| K9N54_RS09425 (K9N54_09415) | 2045462..2046340 | - | 879 | WP_140142865.1 | IS3 family transposase | - |
| K9N54_RS09430 (K9N54_09420) | 2046295..2046603 | - | 309 | WP_005464425.1 | transposase | - |
| K9N54_RS09435 (K9N54_09425) | 2046893..2047135 | + | 243 | WP_000557294.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K9N54_RS09440 (K9N54_09430) | 2047142..2047438 | + | 297 | WP_025793277.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9N54_RS09445 | 2047555..2047635 | - | 81 | Protein_1832 | DUF3265 domain-containing protein | - |
| K9N54_RS09450 (K9N54_09435) | 2048076..2048423 | - | 348 | WP_025793278.1 | cupin domain-containing protein | - |
| K9N54_RS09455 (K9N54_09440) | 2048544..2049065 | - | 522 | WP_015296898.1 | GNAT family N-acetyltransferase | - |
| K9N54_RS09460 (K9N54_09445) | 2049096..2049263 | - | 168 | WP_001883086.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09465 (K9N54_09450) | 2049203..2049505 | - | 303 | WP_025537048.1 | hypothetical protein | - |
| K9N54_RS09470 (K9N54_09455) | 2049652..2050284 | - | 633 | WP_025793279.1 | hypothetical protein | - |
| K9N54_RS09475 (K9N54_09460) | 2050311..2050403 | - | 93 | WP_079725826.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09480 (K9N54_09465) | 2050393..2051196 | - | 804 | WP_025793280.1 | hypothetical protein | - |
| K9N54_RS09485 (K9N54_09470) | 2051336..2051992 | - | 657 | WP_025793281.1 | hypothetical protein | - |
| K9N54_RS09490 | 2052021..2052149 | - | 129 | WP_077672984.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2041179..2166543 | 125364 | |
| - | flank | IS/Tn | - | - | 2042239..2042625 | 386 | |
| - | inside | Integron | - | - | 2043131..2087443 | 44312 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11249.00 Da Isoelectric Point: 9.8450
>T216306 WP_025793277.1 NZ_CP083361:2047142-2047438 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSLLPQNHL
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSLLPQNHL
Download Length: 297 bp
>T216306 NZ_CP113007:2209492-2209956 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8973.13 Da Isoelectric Point: 4.6135
>AT216306 WP_000557294.1 NZ_CP083361:2046893-2047135 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL
Download Length: 243 bp
>AT216306 NZ_CP113007:2209156-2209479 [Staphylococcus aureus]
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
ATGAGAACTTCAGCGGAAATAGGTAAATTAATCAAACAACTACGAAAAGAGAATAATGTGAATTTAACTGATTTTGCAAC
TAAGATAGGTGTCAATAAATCTACCTTATCCCGATATGAAAACGGTAGCAGAAAAATACCTATGGAGGATATAGCTGAGA
TTGCCAATGCATTGAAAGTTACCCCAGAATATTTACTATTAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCA
GCTCATTTAGAAGGAGAATTAACTGATGACGAGTGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAA
GTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|