Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 274585..275141 Replicon plasmid p1
Accession NZ_CP083351
Organism Ensifer adhaerens strain W2-B9

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag LAC81_RS36015 Protein ID WP_223730964.1
Coordinates 274851..275141 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LAC81_RS36010 Protein ID WP_223730963.1
Coordinates 274585..274863 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC81_RS35980 (LAC81_35750) 269692..270462 + 771 WP_223730959.1 ABC transporter ATP-binding protein -
LAC81_RS35985 (LAC81_35755) 270652..271707 - 1056 WP_223730960.1 LacI family DNA-binding transcriptional regulator -
LAC81_RS35990 (LAC81_35760) 271716..271928 - 213 WP_223730961.1 tautomerase family protein -
LAC81_RS35995 (LAC81_35765) 271944..272855 - 912 WP_223730962.1 SMP-30/gluconolactonase/LRE family protein -
LAC81_RS36000 (LAC81_35770) 273206..273949 + 744 Protein_280 substrate-binding domain-containing protein -
LAC81_RS36005 (LAC81_35775) 274184..274306 - 123 Protein_281 oligopeptide ABC transporter ATP-binding protein OppF -
LAC81_RS38250 274295..274395 - 101 Protein_282 hypothetical protein -
LAC81_RS36010 (LAC81_35780) 274585..274863 + 279 WP_223730963.1 CopG family ribbon-helix-helix protein Antitoxin
LAC81_RS36015 (LAC81_35785) 274851..275141 + 291 WP_223730964.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LAC81_RS36020 (LAC81_35790) 275463..275693 - 231 WP_057249963.1 30S ribosomal protein S21 -
LAC81_RS36025 (LAC81_35795) 275839..276633 - 795 WP_223730965.1 L,D-transpeptidase -
LAC81_RS36030 (LAC81_35800) 276998..277561 - 564 WP_223730966.1 cytochrome b/b6 domain-containing protein -
LAC81_RS36035 (LAC81_35805) 277558..277833 - 276 WP_223730967.1 PepSY domain-containing protein -
LAC81_RS36040 277936..278313 + 378 WP_223730968.1 hypothetical protein -
LAC81_RS36045 (LAC81_35815) 278310..278975 + 666 WP_223730969.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..735709 735709


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10925.62 Da        Isoelectric Point: 9.4585

>T216305 WP_223730964.1 NZ_CP083351:274851-275141 [Ensifer adhaerens]
MPQIVFSSAAVRDLERLRKYLQPKSPLAAKRAAEAILKGVQALGAHPKMGRLIDDLPDQYREWLIDFGDSGYITRYRIDE
DVLTILAVRHQKESGF

Download         Length: 291 bp

>T216305 NZ_CP113007:c1410046-1409951 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10680.82 Da        Isoelectric Point: 4.9565

>AT216305 WP_223730963.1 NZ_CP083351:274585-274863 [Ensifer adhaerens]
MASPTSLKLDDELKGRVQHLAEIRRRSSHWIMREAIAQYVEREEKRETLRQDTLDAWEEYQSAGLHATAAEVEKWLSTWG
TDDESAAPECHK

Download         Length: 279 bp

>AT216305 NZ_CP113007:1409864-1409923 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References