Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 164695..165275 Replicon plasmid p1
Accession NZ_CP083351
Organism Ensifer adhaerens strain W2-B9

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LAC81_RS35410 Protein ID WP_223730869.1
Coordinates 164695..165078 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LAC81_RS35415 Protein ID WP_223730870.1
Coordinates 165075..165275 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC81_RS35390 (LAC81_35170) 160122..161465 + 1344 WP_223730866.1 glutamine synthetase family protein -
LAC81_RS35395 (LAC81_35175) 161470..161976 + 507 WP_223730867.1 flavin reductase family protein -
LAC81_RS35400 (LAC81_35180) 162053..163495 + 1443 WP_223730868.1 APC family permease -
LAC81_RS35405 (LAC81_35185) 163500..164089 - 590 Protein_160 hypothetical protein -
LAC81_RS35410 (LAC81_35190) 164695..165078 - 384 WP_223730869.1 type II toxin-antitoxin system VapC family toxin Toxin
LAC81_RS35415 (LAC81_35195) 165075..165275 - 201 WP_223730870.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LAC81_RS35420 (LAC81_35200) 165827..166585 - 759 WP_235693208.1 HipA domain-containing protein -
LAC81_RS35425 (LAC81_35205) 167211..167714 - 504 WP_223730872.1 hypothetical protein -
LAC81_RS35430 (LAC81_35210) 168038..169039 + 1002 WP_223730873.1 IS30 family transposase -
LAC81_RS35435 (LAC81_35215) 169141..169374 - 234 WP_223730874.1 hypothetical protein -
LAC81_RS35440 (LAC81_35220) 169845..169994 - 150 WP_223730875.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..735709 735709
- flank IS/Tn - - 168038..169039 1001


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14063.21 Da        Isoelectric Point: 6.6947

>T216304 WP_223730869.1 NZ_CP083351:c165078-164695 [Ensifer adhaerens]
VILADTSIWIDHFRHADGELRRIIEDDLLLCHPAVIGELALGSLRDRSNVLAVLAAQREALVATHDEVMTMIDRHAIFSM
GIGYTDAHLLASVLLDHRATLWTRDKRLRVAAEKAGALLHLAGNSRN

Download         Length: 384 bp

>T216304 NZ_CP113007:1353710-1353862 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7093.20 Da        Isoelectric Point: 11.4778

>AT216304 WP_223730870.1 NZ_CP083351:c165275-165075 [Ensifer adhaerens]
MRSTINLDDTLIERAKSLTGTKETSALVRQALETLVRVESGKRLIALGGTMPNAEAAPRRRSAAAK

Download         Length: 201 bp

>AT216304 NZ_CP113007:1353086-1353685 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References