Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 2468445..2469325 Replicon chromosome
Accession NZ_CP083350
Organism Ensifer adhaerens strain W2-B9

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC81_RS31390 Protein ID WP_223728559.1
Coordinates 2468816..2469325 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC81_RS31385 Protein ID WP_223728558.1
Coordinates 2468445..2468816 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC81_RS31365 (LAC81_31205) 2464337..2464720 + 384 WP_113538584.1 RidA family protein -
LAC81_RS31370 (LAC81_31210) 2464736..2466724 + 1989 WP_223728555.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
LAC81_RS31375 (LAC81_31215) 2466721..2467590 + 870 WP_223728556.1 hydroxymethylglutaryl-CoA lyase -
LAC81_RS31380 (LAC81_31220) 2467587..2468372 + 786 WP_223728557.1 crotonase/enoyl-CoA hydratase family protein -
LAC81_RS31385 (LAC81_31225) 2468445..2468816 + 372 WP_223728558.1 DUF2384 domain-containing protein Antitoxin
LAC81_RS31390 (LAC81_31230) 2468816..2469325 + 510 WP_223728559.1 RES domain-containing protein Toxin
LAC81_RS31395 (LAC81_31235) 2469391..2470755 - 1365 WP_223728560.1 FAD-binding oxidoreductase -
LAC81_RS31400 (LAC81_31240) 2470881..2472014 - 1134 WP_223728561.1 sulfate/molybdate ABC transporter ATP-binding protein -
LAC81_RS31405 (LAC81_31245) 2472028..2472918 - 891 WP_162768987.1 sulfate ABC transporter permease subunit CysW -
LAC81_RS31410 (LAC81_31250) 2472908..2473774 - 867 WP_223728562.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(8-162)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18736.22 Da        Isoelectric Point: 6.0927

>T216300 WP_223728559.1 NZ_CP083350:2468816-2469325 [Ensifer adhaerens]
MAGSGPVRLWRAYVPRWAHAPLSGEGAARFGGRWNPVGTPAIYAARELSTAWAEYNQGFVQHPALIAQLELRFARLADLT
VAETLSDLGLTEEIHRCEWRDALDRGLLPATHRLQRELSDRDFDGLIYPSFMSPGGTCVALWRWNAGEGAELTVIDPDGR
LPKTPASWL

Download         Length: 510 bp

>T216300 NZ_CP113007:1061494-1061703 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 12998.97 Da        Isoelectric Point: 9.8323

>AT216300 WP_223728558.1 NZ_CP083350:2468445-2468816 [Ensifer adhaerens]
MAAVSFNVSAADYGERQSSFLSARLVADRLGVTLAELARLIGVARNTLTAKSSARKVDAALSVVVRILAMAGEMAGDDSR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT216300 NZ_CP113007:1061189-1061482 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References