Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 1692620..1693500 Replicon chromosome
Accession NZ_CP083347
Organism Ensifer adhaerens strain W2-B

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC80_RS27805 Protein ID WP_223728559.1
Coordinates 1692991..1693500 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC80_RS27800 Protein ID WP_223728558.1
Coordinates 1692620..1692991 (+) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC80_RS27780 (LAC80_27685) 1688512..1688895 + 384 WP_113538584.1 RidA family protein -
LAC80_RS27785 (LAC80_27690) 1688911..1690899 + 1989 WP_223728555.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
LAC80_RS27790 (LAC80_27695) 1690896..1691765 + 870 WP_223728556.1 hydroxymethylglutaryl-CoA lyase -
LAC80_RS27795 (LAC80_27700) 1691762..1692547 + 786 WP_223728557.1 crotonase/enoyl-CoA hydratase family protein -
LAC80_RS27800 (LAC80_27705) 1692620..1692991 + 372 WP_223728558.1 DUF2384 domain-containing protein Antitoxin
LAC80_RS27805 (LAC80_27710) 1692991..1693500 + 510 WP_223728559.1 RES domain-containing protein Toxin
LAC80_RS27810 (LAC80_27715) 1693566..1694930 - 1365 WP_223728560.1 FAD-binding oxidoreductase -
LAC80_RS27815 (LAC80_27720) 1695056..1696189 - 1134 WP_223728561.1 sulfate/molybdate ABC transporter ATP-binding protein -
LAC80_RS27820 (LAC80_27725) 1696203..1697093 - 891 WP_162768987.1 sulfate ABC transporter permease subunit CysW -
LAC80_RS27825 (LAC80_27730) 1697083..1697949 - 867 WP_223728562.1 sulfate ABC transporter permease subunit CysT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(8-162)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18736.22 Da        Isoelectric Point: 6.0927

>T216292 WP_223728559.1 NZ_CP083347:1692991-1693500 [Ensifer adhaerens]
MAGSGPVRLWRAYVPRWAHAPLSGEGAARFGGRWNPVGTPAIYAARELSTAWAEYNQGFVQHPALIAQLELRFARLADLT
VAETLSDLGLTEEIHRCEWRDALDRGLLPATHRLQRELSDRDFDGLIYPSFMSPGGTCVALWRWNAGEGAELTVIDPDGR
LPKTPASWL

Download         Length: 510 bp

>T216292 NZ_CP113005:c1808462-1808358 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 12998.97 Da        Isoelectric Point: 9.8323

>AT216292 WP_223728558.1 NZ_CP083347:1692620-1692991 [Ensifer adhaerens]
MAAVSFNVSAADYGERQSSFLSARLVADRLGVTLAELARLIGVARNTLTAKSSARKVDAALSVVVRILAMAGEMAGDDSR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT216292 NZ_CP113005:1808245-1808300 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References