Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 17520..18160 Replicon plasmid p1
Accession NZ_CP083345
Organism Ensifer adhaerens strain W2-A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LAC78_RS35980 Protein ID WP_223730751.1
Coordinates 17520..17906 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LAC78_RS35985 Protein ID WP_223730752.1
Coordinates 17906..18160 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC78_RS35965 (LAC78_35750) 14641..15435 - 795 WP_223730749.1 hypothetical protein -
LAC78_RS35970 (LAC78_35755) 16090..16482 + 393 WP_223730750.1 hypothetical protein -
LAC78_RS35975 17028..17264 - 237 Protein_12 hypothetical protein -
LAC78_RS35980 (LAC78_35760) 17520..17906 - 387 WP_223730751.1 type II toxin-antitoxin system VapC family toxin Toxin
LAC78_RS35985 (LAC78_35765) 17906..18160 - 255 WP_223730752.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LAC78_RS35990 18319..18777 - 459 WP_223730753.1 type II toxin-antitoxin system VapC family toxin -
LAC78_RS35995 (LAC78_35775) 18777..19019 - 243 WP_223730754.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
LAC78_RS36000 (LAC78_35780) 19249..20898 + 1650 WP_223730755.1 Mu transposase C-terminal domain-containing protein -
LAC78_RS36005 (LAC78_35785) 20889..21812 + 924 WP_223730756.1 TniB family NTP-binding protein -
LAC78_RS39595 22220..22942 + 723 WP_235693206.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB 1..735984 735984


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13924.65 Da        Isoelectric Point: 4.3945

>T216287 WP_223730751.1 NZ_CP083345:c17906-17520 [Ensifer adhaerens]
MVIYTSVLAAIAFNEPEAATFHERIADDPVRLISAASVLEAAMVIETRLGEAAGADLDLWLYKAEVEIVPVTAEHADRAR
RAWRRYGEGRHPVSLNYGDCFSYALAALSGEPLLNKGSDFSQTDIDAA

Download         Length: 387 bp

>T216287 NZ_CP113005:c1457635-1457483 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9569.82 Da        Isoelectric Point: 5.1862

>AT216287 WP_223730752.1 NZ_CP083345:c18160-17906 [Ensifer adhaerens]
MALSIKDHDTEQLARTLAERTGESITLATKRALEERLRRLGCDMRKAAFLEDLEAIQRRWNARPVLDSRTADEILGYDEN
GLPS

Download         Length: 255 bp

>AT216287 NZ_CP113005:c1458259-1457660 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References