Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-Xre
Location 2783791..2784671 Replicon chromosome
Accession NZ_CP083344
Organism Ensifer adhaerens strain W2-A

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC78_RS32785 Protein ID WP_223728559.1
Coordinates 2783791..2784300 (-) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LAC78_RS32790 Protein ID WP_223728558.1
Coordinates 2784300..2784671 (-) Length 124 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC78_RS32765 (LAC78_32580) 2779342..2780208 + 867 WP_223728562.1 sulfate ABC transporter permease subunit CysT -
LAC78_RS32770 (LAC78_32585) 2780198..2781088 + 891 WP_162768987.1 sulfate ABC transporter permease subunit CysW -
LAC78_RS32775 (LAC78_32590) 2781102..2782235 + 1134 WP_223728561.1 sulfate/molybdate ABC transporter ATP-binding protein -
LAC78_RS32780 (LAC78_32595) 2782361..2783725 + 1365 WP_223728560.1 FAD-binding oxidoreductase -
LAC78_RS32785 (LAC78_32600) 2783791..2784300 - 510 WP_223728559.1 RES domain-containing protein Toxin
LAC78_RS32790 (LAC78_32605) 2784300..2784671 - 372 WP_223728558.1 DUF2384 domain-containing protein Antitoxin
LAC78_RS32795 (LAC78_32610) 2784744..2785529 - 786 WP_223728557.1 crotonase/enoyl-CoA hydratase family protein -
LAC78_RS32800 (LAC78_32615) 2785526..2786395 - 870 WP_223728556.1 hydroxymethylglutaryl-CoA lyase -
LAC78_RS32805 (LAC78_32620) 2786392..2788380 - 1989 WP_223728555.1 acetyl/propionyl/methylcrotonyl-CoA carboxylase subunit alpha -
LAC78_RS32810 (LAC78_32625) 2788396..2788779 - 384 WP_113538584.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(8-162)

Antitoxin

Antitoxin Xre/MbcA/ParS-like, toxin-binding domain

(71-120)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18736.22 Da        Isoelectric Point: 6.0927

>T216286 WP_223728559.1 NZ_CP083344:c2784300-2783791 [Ensifer adhaerens]
MAGSGPVRLWRAYVPRWAHAPLSGEGAARFGGRWNPVGTPAIYAARELSTAWAEYNQGFVQHPALIAQLELRFARLADLT
VAETLSDLGLTEEIHRCEWRDALDRGLLPATHRLQRELSDRDFDGLIYPSFMSPGGTCVALWRWNAGEGAELTVIDPDGR
LPKTPASWL

Download         Length: 510 bp

>T216286 NZ_CP113005:1401299-1401394 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 124 a.a.        Molecular weight: 12998.97 Da        Isoelectric Point: 9.8323

>AT216286 WP_223728558.1 NZ_CP083344:c2784671-2784300 [Ensifer adhaerens]
MAAVSFNVSAADYGERQSSFLSARLVADRLGVTLAELARLIGVARNTLTAKSSARKVDAALSVVVRILAMAGEMAGDDSR
AVIWFKHQPIPGWAGKTAYDLVGEGKADKVLAYLEAVRSGVYA

Download         Length: 372 bp

>AT216286 NZ_CP113005:c1401481-1401422 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References