Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2031405..2032066 Replicon chromosome
Accession NZ_CP083344
Organism Ensifer adhaerens strain W2-A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LAC78_RS29485 Protein ID WP_223729078.1
Coordinates 2031405..2031809 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LAC78_RS29490 Protein ID WP_223729077.1
Coordinates 2031806..2032066 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC78_RS39740 2027484..2027615 - 132 WP_268906830.1 hypothetical protein -
LAC78_RS29475 (LAC78_29320) 2028445..2029362 + 918 WP_223729080.1 zincin-like metallopeptidase domain-containing protein -
LAC78_RS29480 (LAC78_29325) 2029826..2031016 - 1191 WP_223729079.1 DUF1173 domain-containing protein -
LAC78_RS29485 (LAC78_29330) 2031405..2031809 - 405 WP_223729078.1 type II toxin-antitoxin system VapC family toxin Toxin
LAC78_RS29490 (LAC78_29335) 2031806..2032066 - 261 WP_223729077.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LAC78_RS29495 (LAC78_29340) 2033039..2033362 + 324 WP_058323403.1 DUF736 family protein -
LAC78_RS29500 (LAC78_29345) 2033698..2033865 + 168 WP_223730445.1 hypothetical protein -
LAC78_RS29505 (LAC78_29350) 2034207..2035172 + 966 WP_223729076.1 IS481 family transposase -
LAC78_RS29510 (LAC78_29355) 2035231..2035985 + 755 WP_223729075.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2034207..2035172 965


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(8-43)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14509.60 Da        Isoelectric Point: 6.4819

>T216285 WP_223729078.1 NZ_CP083344:c2031809-2031405 [Ensifer adhaerens]
VISHLLDTNAVIALIGRKSDRLVSRVLHSPQGSLGLPSVVAYELYFGAQKSAKVQHNLETLRLLMADFSILDFDQNDAFV
AGEIRAALAAKGTPIGPYDVLIAGQAKARGLTLVTNNVGEFNRVENLHVEDWSV

Download         Length: 405 bp

>T216285 NZ_CP113005:c599735-599271 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTTCCATTACGTGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCGATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9792.96 Da        Isoelectric Point: 4.6510

>AT216285 WP_223729077.1 NZ_CP083344:c2032066-2031806 [Ensifer adhaerens]
MPHLARVFQSGNSQAVRLPKEFRFNVERVEITQEGDALILRPHVEAGEPWSSLKAALARGMTDDFMESGREQPEQQDRPE
LDAVFQ

Download         Length: 261 bp

>AT216285 NZ_CP113005:c600062-599748 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGTAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References