216257

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4357141..4357955 Replicon chromosome
Accession NZ_CP083273
Organism Escherichia coli strain BL21-RIPL

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag K9U36_RS21145 Protein ID WP_001054376.1
Coordinates 4357141..4357398 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag K9U36_RS21150 Protein ID WP_001309181.1
Coordinates 4357410..4357955 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U36_RS21120 (4352429) 4352429..4353535 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
K9U36_RS21125 (4353600) 4353600..4354580 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
K9U36_RS21130 (4354690) 4354690..4354895 + 206 Protein_4160 HNH endonuclease -
K9U36_RS21135 (4355163) 4355163..4356403 - 1241 Protein_4161 helicase YjhR -
K9U36_RS21140 (4356519) 4356519..4356650 + 132 WP_001309182.1 hypothetical protein -
K9U36_RS21145 (4357141) 4357141..4357398 + 258 WP_001054376.1 YjhX family toxin Toxin
K9U36_RS21150 (4357410) 4357410..4357955 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
K9U36_RS21155 (4358011) 4358011..4358757 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
K9U36_RS21160 (4358926) 4358926..4359144 + 219 Protein_4166 hypothetical protein -
K9U36_RS21165 (4359182) 4359182..4359298 + 117 Protein_4167 VOC family protein -
K9U36_RS21170 (4359543) 4359543..4360664 + 1122 WP_000010829.1 M42 family metallopeptidase -
K9U36_RS21175 (4360661) 4360661..4360939 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
K9U36_RS21180 (4360951) 4360951..4362264 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T216257 WP_001054376.1 NZ_CP083273:4357141-4357398 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

>T216257 NZ_CP112997:2196186-2196563 [Mycobacterium tuberculosis variant bovis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT216257 WP_001309181.1 NZ_CP083273:4357410-4357955 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp

>AT216257 NZ_CP112997:2196605-2197054 [Mycobacterium tuberculosis variant bovis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References