Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 3473720..3474306 Replicon chromosome
Accession NZ_CP083263
Organism Escherichia coli strain JNU

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag K6T58_RS16730 Protein ID WP_042014162.1
Coordinates 3473720..3473950 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag K6T58_RS16735 Protein ID WP_000593555.1
Coordinates 3473947..3474306 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6T58_RS16720 (3469757) 3469757..3472492 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
K6T58_RS16725 (3472492) 3472492..3473616 + 1125 WP_001314210.1 ABC transporter permease -
K6T58_RS16730 (3473720) 3473720..3473950 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
K6T58_RS16735 (3473947) 3473947..3474306 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K6T58_RS16740 (3474426) 3474426..3474827 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
K6T58_RS16745 (3474833) 3474833..3475639 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
K6T58_RS16750 (3475636) 3475636..3476400 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
K6T58_RS16755 (3476400) 3476400..3477233 - 834 WP_069915052.1 nickel ABC transporter permease subunit NikC -
K6T58_RS16760 (3477230) 3477230..3478174 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T216225 WP_042014162.1 NZ_CP083263:3473720-3473950 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T216225 NZ_CP112996:3728944-3729201 [Mycobacterium tuberculosis variant bovis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT216225 WP_000593555.1 NZ_CP083263:3473947-3474306 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT216225 NZ_CP112996:3728672-3728947 [Mycobacterium tuberculosis variant bovis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References