Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2090696..2091173 Replicon chromosome
Accession NZ_CP083259
Organism Staphylococcus aureus strain HL25274

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K3A98_RS10515 Protein ID WP_000052076.1
Coordinates 2090985..2091173 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K3A98_RS10510 Protein ID WP_001059690.1
Coordinates 2090696..2090956 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A98_RS10475 (2086065) 2086065..2086781 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
K3A98_RS10480 (2086929) 2086929..2087351 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
K3A98_RS10485 (2087750) 2087750..2088244 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
K3A98_RS10490 (2088400) 2088400..2089017 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
K3A98_RS10495 (2089114) 2089114..2089695 - 582 WP_001140696.1 histidine phosphatase family protein -
K3A98_RS10500 (2089919) 2089919..2090155 + 237 WP_000368687.1 hypothetical protein -
K3A98_RS10505 (2090152) 2090152..2090355 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
K3A98_RS10510 (2090696) 2090696..2090956 + 261 WP_001059690.1 hypothetical protein Antitoxin
K3A98_RS10515 (2090985) 2090985..2091173 + 189 WP_000052076.1 hypothetical protein Toxin
K3A98_RS10520 (2091361) 2091361..2091930 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
K3A98_RS10525 (2092018) 2092018..2092290 + 273 WP_001004400.1 hypothetical protein -
K3A98_RS10530 (2092363) 2092363..2092581 + 219 WP_000005884.1 hypothetical protein -
K3A98_RS10535 (2093077) 2093077..2093277 - 201 WP_001059082.1 cold-shock protein -
K3A98_RS10540 (2093634) 2093634..2094320 - 687 WP_001812985.1 thermonuclease family protein -
K3A98_RS10545 (2094661) 2094661..2095206 - 546 WP_000824465.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T216205 WP_000052076.1 NZ_CP083259:2090985-2091173 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T216205 NZ_CP112996:c2218096-2217752 [Mycobacterium tuberculosis variant bovis]
GTGGTGATTAGTCGTGCCGAGATCTACTGGGCTGACCTCGGGCCGCCATCAGGCAGTCAGCCGGCGAAGCGCCGCCCGGT
GCTCGTAATCCAGTCAGATCCGTACAACGCAAGTCGCCTTGCCACTGTGATCGCAGCGGTGATCACGTCCAATACGGCGC
TGGCGGCAATGCCCGGCAACGTGTTCTTGCCCGCGACCACAACGCGACTGCCACGTGACTCGGTCGTCAACGTCACGGCG
ATTGTCACGCTCAACAAGACTGACCTCACCGACCGAGTTGGGGAGGTGCCAGCGAGCTTGATGCACGAGGTTGACCGAGG
ACTTCGTCGCGTACTGGACCTTTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT216205 WP_001059690.1 NZ_CP083259:2090696-2090956 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT216205 NZ_CP112996:c2218338-2218090 [Mycobacterium tuberculosis variant bovis]
ATGAAGACAGCTATTTCTCTGCCGGATGAGACGTTCGATCGGGTATCGCGGCGTGCGAGTGAGCTCGGCATGAGTCGGTC
CGAGTTCTTCACGAAGGCTGCGCAGCGCTACCTGCACGAGCTGGACGCCCAATTGCTCACGGGCCAGATCGACAGGGCTC
TAGAGAGCATCCATGGCACCGACGAAGCGGAGGCCCTCGCCGTGGCCAACGCATACCGCGTGCTAGAAACCATGGACGAT
GAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References