Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 985550..986326 Replicon chromosome
Accession NZ_CP083259
Organism Staphylococcus aureus strain HL25274

Toxin (Protein)


Gene name tsbT Uniprot ID A0A0U1MPP1
Locus tag K3A98_RS05125 Protein ID WP_000031104.1
Coordinates 986174..986326 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag K3A98_RS05120 Protein ID WP_001251224.1
Coordinates 985550..986149 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A98_RS05100 (981466) 981466..982923 + 1458 WP_000649908.1 ABC transporter permease subunit -
K3A98_RS05105 (982916) 982916..983638 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
K3A98_RS05110 (983789) 983789..984916 + 1128 WP_000379991.1 tRNA epoxyqueuosine(34) reductase QueG -
K3A98_RS05115 (984921) 984921..985391 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
K3A98_RS05120 (985550) 985550..986149 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
K3A98_RS05125 (986174) 986174..986326 + 153 WP_000031104.1 SAS053 family protein Toxin
K3A98_RS05130 (987153) 987153..987548 + 396 WP_000901020.1 hypothetical protein -
K3A98_RS05135 (987744) 987744..989129 + 1386 WP_000116238.1 class II fumarate hydratase -
K3A98_RS05140 (989586) 989586..990407 - 822 WP_031875108.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5963.31 Da        Isoelectric Point: 3.9075

>T216203 WP_000031104.1 NZ_CP083259:986174-986326 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNDQEKNSEEESQ

Download         Length: 153 bp

>T216203 NZ_CP112996:c2209279-2208860 [Mycobacterium tuberculosis variant bovis]
ATGATCGTGGACACAAGCGCCGTGGTGGCCCTGGTTCAAGGCGAGCGGCCGCACGCCACCCTGGTCGCGGCCGCCCTGGC
CGGCGCCCATAGCCCCGTCATGTCTGCACCCACCGTCGCCGAATGCCTGATTGTCTTGACCGCCCGTCACGGCCCCGTTG
CGCGCACGATCTTCGAACGACTTCGCAGCGAAATCGGCTTGAGCGTGTCATCTTTCACCGCCGAGCATGCCGCTGCCACG
CAACGAGCCTTTCTGCGATACGGCAAGGGGCGCCACCGCGCGGCTCTCAACTTCGGAGACTGTATGACGTACGCGACCGC
CCAGCTGGGCCACCAACCACTGCTGGCCGTCGGCAACGACTTCCCGCAAACCGACCTTGAGTTCCGCGGCGTCGTCGGCT
ACTGGCCAGGCGTCGCGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT216203 WP_001251224.1 NZ_CP083259:985550-986149 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT216203 NZ_CP112996:c2209548-2209288 [Mycobacterium tuberculosis variant bovis]
GTGGCGCTGAATATCAAAGACCCTGAGGTAGACCGACTAGCCGCCGAACTCGCTGACCGGCTGCACACCAGCAAGACTGC
CGCCATCCGGCATGCCCTGTCTGCCCAGCTGGCGTTTTTGGAGTCGCGCGCCGGCGACCGTGAGGCACAACTTCTCGACA
TCTTGCGTACCGAAATCTGGCCCCTGCTTGCCGACCGCTCCCCCATCACCAAGCTCGAGCGCGAACAAATCCTCGGCTAC
GACCCCGCAACCGGAGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MPP1

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References