Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 753548..754062 Replicon chromosome
Accession NZ_CP083259
Organism Staphylococcus aureus strain HL25274

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag K3A98_RS03685 Protein ID WP_000581795.1
Coordinates 753853..754062 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag K3A98_RS03680 Protein ID WP_000138930.1
Coordinates 753548..753841 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A98_RS03660 (748877) 748877..749518 + 642 WP_223671414.1 thiamine phosphate synthase -
K3A98_RS03665 (749604) 749604..750476 + 873 WP_000725802.1 membrane protein insertase YidC -
K3A98_RS03670 (751223) 751223..751870 - 648 WP_001187623.1 HD domain-containing protein -
K3A98_RS03675 (751898) 751898..753382 - 1485 WP_000571561.1 cardiolipin synthase -
K3A98_RS03680 (753548) 753548..753841 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
K3A98_RS03685 (753853) 753853..754062 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
K3A98_RS03690 (754190) 754190..754327 + 138 WP_000828354.1 Lmo0850 family protein -
K3A98_RS03695 (754591) 754591..755793 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K3A98_RS03700 (756111) 756111..757181 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
K3A98_RS03705 (757196) 757196..758554 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T216197 WP_000581795.1 NZ_CP083259:753853-754062 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T216197 NZ_CP112996:1755619-1756023 [Mycobacterium tuberculosis variant bovis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT216197 WP_000138930.1 NZ_CP083259:753548-753841 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT216197 NZ_CP112996:1755410-1755613 [Mycobacterium tuberculosis variant bovis]
ATGTCGCGCACCAACATCGACATCGATGACGAACTTGCCGCCGAGGTCATGCGCAGGTTCGGTCTGACCACCAAGAGGGC
GGCGGTCGACCTTGCCCTACGACGGTTGGTCGGGTCGCCGTTGAGCCGTGAGTTTCTGCTCGGGCTGGAAGGCGTCGGCT
GGGAAGGCGACCTGGATGACTTGCGAAGCGATCGCCCAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References