Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1414300..1415180 Replicon chromosome
Accession NZ_CP083257
Organism Bifidobacterium longum subsp. longum strain BCBL-583

Toxin (Protein)


Gene name relE Uniprot ID A0A4R0U778
Locus tag BCBL_RS06080 Protein ID WP_065443985.1
Coordinates 1414300..1414791 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8APN1
Locus tag BCBL_RS06085 Protein ID WP_007057212.1
Coordinates 1414788..1415180 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCBL_RS06060 (BCBL_1230) 1409352..1410614 + 1263 WP_223616533.1 histidine kinase -
BCBL_RS06065 (BCBL_1231) 1410649..1411374 + 726 WP_007056206.1 response regulator transcription factor -
BCBL_RS06070 (BCBL_1232) 1411414..1412055 + 642 WP_007052627.1 GNAT family N-acetyltransferase -
BCBL_RS06075 (BCBL_1233) 1412145..1414250 + 2106 WP_007052626.1 DUF262 domain-containing protein -
BCBL_RS06080 (BCBL_1234) 1414300..1414791 - 492 WP_065443985.1 type II toxin-antitoxin system VapC family toxin Toxin
BCBL_RS06085 (BCBL_1235) 1414788..1415180 - 393 WP_007057212.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BCBL_RS06090 (BCBL_1236) 1415326..1418025 - 2700 WP_060620904.1 aconitate hydratase AcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-61)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18563.76 Da        Isoelectric Point: 6.2348

>T216196 WP_065443985.1 NZ_CP083257:c1414791-1414300 [Bifidobacterium longum subsp. longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDMFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDLIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

>T216196 NZ_CP112996:1687782-1688099 [Mycobacterium tuberculosis variant bovis]
GTGAACGCGCCGTTGCGTGGTCAGGTCTATCGATGCGACCTCGGATACGGGGCCAAACCGTGGCTCATCGTCTCCAACAA
CGCCCGCAACCGTCACACCGCCGACGTGGTGGCTGTGCGCCTGACAACAACGCGGAGAACCATACCGACCTGGGTCGCCA
TGGGCCCCAGCGATCCATTGACCGGATACGTCAACGCGGACAACATCGAGACCCTCGGCAAAGACGAGCTCGGTGACTAC
CTCGGTGAGGTCACGCCGGCGACGATGAACAAAATCAACACGGCGCTCGCGACCGCGCTGGGGCTACCGTGGCCATGA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15147.29 Da        Isoelectric Point: 5.8624

>AT216196 WP_007057212.1 NZ_CP083257:c1415180-1414788 [Bifidobacterium longum subsp. longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp

>AT216196 NZ_CP112996:1687483-1687785 [Mycobacterium tuberculosis variant bovis]
GTGCCGTTTCTGGTTGCATTATCCGGTATCATCTCGGGCGTGCGTGATCATTCGATGACCGTGCGGCTCGACCAGCAAAC
TCGCCAGCGCCTGCAAGACATTGTGAAAGGCGGATACCGGAGCGCTAATGCGGCGATCGTCGACGCCATCAACAAGCGCT
GGGAGGCGCTACACGATGAGCAACTCGACGCCGCCTACGCGGCCGCGATCCATGACAATCCGGCGTACCCGTACGAGTCT
GAGGCCGAACGGAGCGCCGCGCGGGCCCGGCGCAACGCCAGGCAGCAGCGCTCGGCACAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4R0U778

Antitoxin

Source ID Structure
AlphaFold DB F8APN1

References