Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 175922..176565 Replicon plasmid pB
Accession NZ_CP083241
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9D25_RS23170 Protein ID WP_244451173.1
Coordinates 176176..176565 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K9D25_RS23165 Protein ID WP_244451172.1
Coordinates 175922..176176 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS23150 (K9D25_23150) 171890..173086 - 1197 WP_244451103.1 TniQ family protein -
K9D25_RS23155 (K9D25_23155) 173083..174006 - 924 WP_244451104.1 TniB family NTP-binding protein -
K9D25_RS23160 (K9D25_23160) 173997..175640 - 1644 WP_244451105.1 Mu transposase C-terminal domain-containing protein -
K9D25_RS23165 (K9D25_23165) 175922..176176 + 255 WP_244451172.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K9D25_RS23170 (K9D25_23170) 176176..176565 + 390 WP_244451173.1 type II toxin-antitoxin system VapC family toxin Toxin
K9D25_RS23175 (K9D25_23175) 176577..177647 + 1071 WP_244451174.1 site-specific integrase -
K9D25_RS23180 (K9D25_23180) 177670..178080 - 411 Protein_164 type II toxin-antitoxin system VapC family toxin -
K9D25_RS23185 (K9D25_23185) 178077..178310 - 234 WP_244451175.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
K9D25_RS23190 (K9D25_23190) 178386..179615 - 1230 WP_244451176.1 plasmid replication protein RepC -
K9D25_RS23195 (K9D25_23195) 179813..180817 - 1005 WP_244451177.1 plasmid partitioning protein RepB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..232090 232090


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14206.03 Da        Isoelectric Point: 4.5152

>T216193 WP_244451173.1 NZ_CP083241:176176-176565 [Ancylobacter polymorphus]
MVIDTSAIIAIFFNEPDAALYRERIAEDSVRLMSAATLVEAAMVIEARYGDTGGAELDLWLHKAEVEIVSVTDDHADQAR
RAWRRYGKGRHPAGLNYGDCFSYALAVLSGEPLLFKGADFAQTDIEAVR

Download         Length: 390 bp

>T216193 NZ_CP112996:c1390301-1390008 [Mycobacterium tuberculosis variant bovis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9309.58 Da        Isoelectric Point: 5.1972

>AT216193 WP_244451172.1 NZ_CP083241:175922-176176 [Ancylobacter polymorphus]
MALSIKDPETERLARALAARTGESLTVATRRAIEERLKRTGTGARRAALLEDMEAMQRRLSALPVLDDRSPEEMIGYDEN
GVPN

Download         Length: 255 bp

>AT216193 NZ_CP112996:c1390567-1390298 [Mycobacterium tuberculosis variant bovis]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References