Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 26860..27458 Replicon plasmid pA
Accession NZ_CP083240
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K9D25_RS21155 Protein ID WP_244451078.1
Coordinates 26860..27153 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K9D25_RS21160 Protein ID WP_244451079.1
Coordinates 27150..27458 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS21145 (K9D25_21145) 22959..24737 - 1779 WP_244451076.1 hypothetical protein -
K9D25_RS21150 (K9D25_21150) 24775..25935 - 1161 WP_244451077.1 tyrosine-type recombinase/integrase -
K9D25_RS21155 (K9D25_21155) 26860..27153 - 294 WP_244451078.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9D25_RS21160 (K9D25_21160) 27150..27458 - 309 WP_244451079.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9D25_RS21165 (K9D25_21165) 27586..28512 - 927 WP_244451080.1 zincin-like metallopeptidase domain-containing protein -
K9D25_RS21170 (K9D25_21170) 28819..29406 - 588 WP_244451081.1 hypothetical protein -
K9D25_RS21175 (K9D25_21175) 29896..30225 - 330 WP_244451082.1 hypothetical protein -
K9D25_RS21180 (K9D25_21180) 30222..30458 - 237 Protein_31 hypothetical protein -
K9D25_RS21185 (K9D25_21185) 30519..30956 + 438 WP_244451083.1 hypothetical protein -
K9D25_RS21190 (K9D25_21190) 31245..31763 + 519 WP_244451084.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..287647 287647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-54)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10569.00 Da        Isoelectric Point: 9.6939

>T216191 WP_244451078.1 NZ_CP083240:c27153-26860 [Ancylobacter polymorphus]
VKLVWSAYALSDRDGIFSHIEADSSAAAASVDERIAAAARRLREFPESGRPGRIHGTRELVIAGTPYVAAYVVTKTTVRI
LRVLHGAQRWPESLPEG

Download         Length: 294 bp

>T216191 NZ_CP112996:1240993-1241367 [Mycobacterium tuberculosis variant bovis]
GTGATCCTGGTCGACACTTCGGTATGGATTGAGCACCTGCGCGCCGCCGACGCGCGACTCGTCGAGCTGCTGGGCGATGA
CGAGGCCGGTTGCCATCCGCTCGTCATCGAGGAGCTGGCGCTTGGCTCGATCAAGCAGCGAGACGTTGTTCTCGATCTGT
TGGCCAACCTCTACCAGTTTCCGGTGGTGACCCACGACGAAGTGTTGCGGCTTGTCGGTCGGCGGCGGTTGTGGGGTCGG
GGACTCGGTGCCGTCGATGCCAACCTTCTTGGTTCGGTGGCTCTGGTTGGCGGCGCGCGACTATGGACGCGGGACAAGCG
GTTGAAGGCGGCGTGCGCGGAAAGCGGTGTTGCGCTGGCTGAGGAAGTGTCCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11125.42 Da        Isoelectric Point: 4.7132

>AT216191 WP_244451079.1 NZ_CP083240:c27458-27150 [Ancylobacter polymorphus]
MAANALVQTRIDAEIRDRASAVLESMGLTVSDAVRILLTRTANEGALPLELVANSEAHDAWFRAKVLEALNDTRPDISDD
EAEAHFAERRAAARRRASDVPT

Download         Length: 309 bp

>AT216191 NZ_CP112996:1240799-1240996 [Mycobacterium tuberculosis variant bovis]
ATGAGGACGACGGTGACCGTTGACGACGCCTTGTTAGCCAAAGCGGCCGAATTGACTGGGGTGAAAGAGAAGTCGACGCT
CCTGCGCGAGGGGTTGCAGACACTGGTCCGGGTGGAGAGCGCCCGGCGGTTGGCGGCTCTCGGCGGCACCGACCCGCAAG
CTACCGCGGCGCCGAGACGCCGGACGTCGCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References