Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 3056243..3056837 Replicon chromosome
Accession NZ_CP083239
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K9D25_RS14390 Protein ID WP_244376256.1
Coordinates 3056243..3056539 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag K9D25_RS14395 Protein ID WP_244376258.1
Coordinates 3056544..3056837 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS14360 (K9D25_14360) 3051341..3052288 - 948 WP_244376244.1 DMT family transporter -
K9D25_RS14365 (K9D25_14365) 3052397..3053575 - 1179 WP_244376246.1 FAD-dependent monooxygenase -
K9D25_RS14370 (K9D25_14370) 3053585..3053833 - 249 WP_244376248.1 zinc-finger domain-containing protein -
K9D25_RS14375 (K9D25_14375) 3054000..3054986 + 987 WP_244376250.1 hypothetical protein -
K9D25_RS14380 (K9D25_14380) 3055007..3055375 + 369 WP_244376252.1 DUF4087 domain-containing protein -
K9D25_RS14385 (K9D25_14385) 3055446..3056198 + 753 WP_244376254.1 alpha/beta hydrolase -
K9D25_RS14390 (K9D25_14390) 3056243..3056539 + 297 WP_244376256.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9D25_RS14395 (K9D25_14395) 3056544..3056837 + 294 WP_244376258.1 putative addiction module antidote protein Antitoxin
K9D25_RS14400 (K9D25_14400) 3057185..3058045 + 861 WP_244376260.1 serine O-acetyltransferase -
K9D25_RS14405 (K9D25_14405) 3058159..3058371 + 213 WP_018391302.1 DUF3126 family protein -
K9D25_RS14410 (K9D25_14410) 3058377..3058907 + 531 WP_244376262.1 gamma carbonic anhydrase family protein -
K9D25_RS14415 (K9D25_14415) 3058934..3059470 + 537 WP_244376264.1 GNAT family protein -
K9D25_RS14420 (K9D25_14420) 3059467..3060123 - 657 WP_244376266.1 transglutaminase-like cysteine peptidase -
K9D25_RS14425 (K9D25_14425) 3060355..3061134 + 780 WP_244376268.1 rhomboid family intramembrane serine protease -
K9D25_RS14430 (K9D25_14430) 3061290..3061721 + 432 WP_244376270.1 CBS domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-86)

Antitoxin

Uncharacterized protein HI1420

(6-94)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10953.60 Da        Isoelectric Point: 9.9950

>T216190 WP_244376256.1 NZ_CP083239:3056243-3056539 [Ancylobacter polymorphus]
MVEVRQTAEFVRWFTRLRDEAAAARILARIRRLSLGNPGDAKPVGEGVSELRIDYGPGYRVYFVQRGGVLAILLCGGDKH
SQDKDIPAAKALAREWKE

Download         Length: 297 bp

>T216190 NZ_CP112996:c1232354-1232043 [Mycobacterium tuberculosis variant bovis]
ATGCGACCTATCCACATCGCACAGCTTGACAAGGCTAGACCCGTCCTGATCCTTACCCGCGAGGTCGTACGTCCGCACCT
CACGAACGTCACCGTCGCCCCGATCACGACAACCGTGCGTGGGCTAGCCACCGAAGTCCCGGTAGACGCGGTGAACGGGC
TGAATCAACCGTCAGTCGTCAGCTGCGACAACATCCAAACGATCCCGGTGTGTGACCTTGGTCGTCAAATCGGCTACCTG
CTCGCGTCGCAGGAGCCGGCTCTAGCCGAGGCCATCGGCAACGCGTTCGACCTCGATTGGGTGGTGGCATAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10044.47 Da        Isoelectric Point: 4.7335

>AT216190 WP_244376258.1 NZ_CP083239:3056544-3056837 [Ancylobacter polymorphus]
MALETTPWHAADHLDTPESIAAYLEAIFEDGDPALIAAGLGDIARSKGMTKIARDAGVTREALYKALSADGDPRLSTLLG
VVRALGLTLTVAPKSAA

Download         Length: 294 bp

>AT216190 NZ_CP112996:c1232674-1232354 [Mycobacterium tuberculosis variant bovis]
ATGTACCTACCCTGGGGGGTCGTCCTCGCCGGCGGCGCGAACGGTTTTGGGGCGGGTGCATACCAAACTGGTACCATCTG
TGAAGTGAGTACACAGATTGCGGTTCGCTTGCCCGATGAGATTGTCGCGTTCATCGACGACGAAGTCCGGGGACAGCATG
CCCGTAGCCGTGCGGCTGTCGTGCTGCGGGCGCTGGAACGGGAACGCCGCCGTCGTCTCGCCGAACGCGACGCGGAGATC
CTCGCCACCAACACGTCAGCCACGGGTGATCTGGATACGCTGGCCGGCCACTGCGCTCGTACCGCCCTCGACATCGACTG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References