Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2231178..2231716 Replicon chromosome
Accession NZ_CP083239
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag K9D25_RS10525 Protein ID WP_244375085.1
Coordinates 2231393..2231716 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag K9D25_RS10520 Protein ID WP_244375084.1
Coordinates 2231178..2231396 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS10500 (K9D25_10500) 2227502..2228242 + 741 WP_244375080.1 acetoacetate decarboxylase -
K9D25_RS10505 (K9D25_10505) 2228247..2229206 - 960 WP_244375081.1 nickel/cobalt transporter -
K9D25_RS10510 (K9D25_10510) 2229203..2229841 - 639 WP_244375082.1 DUF1007 family protein -
K9D25_RS10515 (K9D25_10515) 2229988..2231025 - 1038 WP_244375083.1 aspartate-semialdehyde dehydrogenase -
K9D25_RS10520 (K9D25_10520) 2231178..2231396 + 219 WP_244375084.1 antitoxin MazE family protein Antitoxin
K9D25_RS10525 (K9D25_10525) 2231393..2231716 + 324 WP_244375085.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
K9D25_RS10530 (K9D25_10530) 2231731..2232126 - 396 WP_244375086.1 rhodanese-like domain-containing protein -
K9D25_RS10535 (K9D25_10535) 2232131..2233447 - 1317 WP_244375087.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
K9D25_RS10540 (K9D25_10540) 2233512..2234066 - 555 WP_244375088.1 transcriptional repressor -
K9D25_RS10545 (K9D25_10545) 2234261..2234719 + 459 WP_244375089.1 hypothetical protein -
K9D25_RS10550 (K9D25_10550) 2234844..2235626 + 783 WP_244375090.1 3-hydroxybutyrate dehydrogenase -
K9D25_RS10555 (K9D25_10555) 2235668..2236429 + 762 WP_244375091.1 RNA pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-106)

Antitoxin

Antitoxin MazE-like

(6-68)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11531.51 Da        Isoelectric Point: 8.9153

>T216188 WP_244375085.1 NZ_CP083239:2231393-2231716 [Ancylobacter polymorphus]
VMRGHLVTVSLPGDIGKPRPALVIQADQFAETATVTVLPLSGTLVDAPLIRIPVEPSEANGLRKSSQIMVDKPMTIRRDR
TGPSFGQLEDEVMLRVTRSLALFLGLG

Download         Length: 324 bp

>T216188 NZ_CP112996:1015392-1015826 [Mycobacterium tuberculosis variant bovis]
ATGGCGAAACTGTCCGGATCCATCGACGTACCGCTGCCACCGGAGGAAGCCTGGATGCACGCCTCCGATCTGACTCGTTA
CCGAGAGTGGCTGACCATCCACAAGGTATGGCGCAGCAAGTTGCCCGAAGTGCTCGAGAAGGGCACGGTCGTCGAGTCGT
ATGTCGAGGTCAAGGGCATGCCCAACCGGATCAAGTGGACGATCGTGCGGTACAAACCCCCGGAGGGCATGACGCTCAAC
GGCGACGGTGTGGGTGGTGTCAAAGTCAAGCTGATCGCTAAGGTAGCGCCGAAAGAGCACGGCTCCGTCGTCAGCTTCGA
TGTGCACCTCGGCGGCCCGGCCCTGCTCGGGCCGATCGGCATGATCGTCGCCGCTGCATTGCGAGCCGACATCCGCGAAT
CGCTGCAGAACTTCGTCACGGTGTTTGCCGGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8164.16 Da        Isoelectric Point: 9.9575

>AT216188 WP_244375084.1 NZ_CP083239:2231178-2231396 [Ancylobacter polymorphus]
MATSVRARVQRRRDALRAAGLRPVQIWLPDTRRPGFADECRRQSRNVARADLADQDVQSFIDAAWADVVADE

Download         Length: 219 bp

>AT216188 NZ_CP112996:1015207-1015386 [Mycobacterium tuberculosis variant bovis]
ATGGGAATCCTGGACAAGGTAAAGAACCTGCTGTCGCAGAACGCCGACAAGGTCGAGACGGTGATCAACAAAGCGGGCGA
ATTCGTCGACGAGCAGACGCAAGGCAATTATTCTGACGCCATCCACAAGCTGCAGGACGCGGCCAGCAACGTCGTCGGCA
TGAGCGACCAGCAGAGCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References