Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1302107..1302780 Replicon chromosome
Accession NZ_CP083239
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9D25_RS06165 Protein ID WP_244449992.1
Coordinates 1302358..1302780 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K9D25_RS06160 Protein ID WP_244449991.1
Coordinates 1302107..1302361 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS06145 (K9D25_06145) 1297558..1299621 + 2064 WP_244449988.1 ParB/RepB/Spo0J family partition protein -
K9D25_RS06150 (K9D25_06150) 1299691..1300725 + 1035 WP_244449989.1 toprim domain-containing protein -
K9D25_RS06155 (K9D25_06155) 1301096..1302022 + 927 WP_244449990.1 DUF2493 domain-containing protein -
K9D25_RS06160 (K9D25_06160) 1302107..1302361 + 255 WP_244449991.1 plasmid stabilization protein Antitoxin
K9D25_RS06165 (K9D25_06165) 1302358..1302780 + 423 WP_244449992.1 type II toxin-antitoxin system VapC family toxin Toxin
K9D25_RS06170 (K9D25_06170) 1303063..1303230 + 168 WP_188079217.1 hypothetical protein -
K9D25_RS06175 (K9D25_06175) 1303354..1303791 + 438 WP_244449993.1 hypothetical protein -
K9D25_RS06180 (K9D25_06180) 1304424..1304750 + 327 WP_244449994.1 DUF736 domain-containing protein -
K9D25_RS06185 (K9D25_06185) 1304835..1305083 - 249 WP_244449995.1 helix-turn-helix transcriptional regulator -
K9D25_RS06190 (K9D25_06190) 1305332..1305598 + 267 WP_149577236.1 DUF2285 domain-containing protein -
K9D25_RS06195 (K9D25_06195) 1305717..1306058 + 342 WP_244449996.1 DUF6499 domain-containing protein -
K9D25_RS06200 (K9D25_06200) 1305967..1306449 + 483 WP_244450812.1 DUF2285 domain-containing protein -
K9D25_RS06205 (K9D25_06205) 1306572..1306853 + 282 WP_132036201.1 helix-turn-helix domain-containing protein -
K9D25_RS06210 (K9D25_06210) 1306865..1307752 + 888 WP_244449997.1 replication initiator protein A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1295585..1361229 65644


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14968.04 Da        Isoelectric Point: 4.4408

>T216187 WP_244449992.1 NZ_CP083239:1302358-1302780 [Ancylobacter polymorphus]
VILLDTNVISEAMKPTPDDTVRAWLDEQAAETLYLSSVTIAELLYGIGALPAGKRQDRLTEALDGLMELFADRVLPFDIA
AARRYADLAVKARAAGKGFPTPDGYIAAIAASRGFTVATRDTSAFDAAGVAVINPWNVER

Download         Length: 423 bp

>T216187 NZ_CP112996:843320-843748 [Mycobacterium tuberculosis variant bovis]
ATGTTCCTTCTCGACGCCAACGTGCTGCTGGCTGCACACCGCGGTGACCACCCGAATCACCGAACCGTCCGCCCCTGGTT
CGATCGACTGCTCGCGGCTGACGACCCCTTCACAGTGCCGAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCAACGAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCAGAGGCATTCGCATTCGTCGAAGCCGTCACCGCCCAGCCCCATCACCTT
CCGACGAACCCCGGTCCCAGACACCTCATGCTGCTGCGAAAACTCTGCGACGAGGCCGACGCATCGGGCGACTTGATACC
TGACGCGGTACTCGCGGCCATAGCAGTGGGGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTTGCCT
CGGTGCGCCACATTCGCCCGCCGCTCTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9409.61 Da        Isoelectric Point: 7.2069

>AT216187 WP_244449991.1 NZ_CP083239:1302107-1302361 [Ancylobacter polymorphus]
MPAVTIRNLSEATHRALKVRAAQHGRSTEAEMRDILETAVRPDTRLRLGTALAERSRRLGLTNEDIDALSPARDRTPDEP
MSFE

Download         Length: 255 bp

>AT216187 NZ_CP112996:843039-843296 [Mycobacterium tuberculosis variant bovis]
ATGCGCACCACGGTGTCAATCTCCGATGAAATACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGTCAATCGCTGGG
CGCTGTGATCGAGGACGCCCTTCGGCGGGAGTTCGCCGCCGCCCACGTCGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCATCGACCTGACCTCGAATAGAGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCCCGGAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References