Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 87901..88558 Replicon chromosome
Accession NZ_CP083239
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9D25_RS00385 Protein ID WP_279613767.1
Coordinates 87901..88326 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag K9D25_RS00390 Protein ID WP_244378185.1
Coordinates 88319..88558 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS00355 (K9D25_00355) 83317..83922 - 606 WP_279613766.1 TetR family transcriptional regulator C-terminal domain-containing protein -
K9D25_RS00360 (K9D25_00360) 83983..84939 + 957 WP_244378178.1 DMT family transporter -
K9D25_RS00365 (K9D25_00365) 85012..85848 - 837 WP_244378179.1 aldo/keto reductase -
K9D25_RS00370 (K9D25_00370) 85971..86969 + 999 WP_244378181.1 hypothetical protein -
K9D25_RS00375 (K9D25_00375) 87077..87565 + 489 WP_244378183.1 hypothetical protein -
K9D25_RS00380 (K9D25_00380) 87601..87858 + 258 WP_244378184.1 hypothetical protein -
K9D25_RS00385 (K9D25_00385) 87901..88326 - 426 WP_279613767.1 type II toxin-antitoxin system VapC family toxin Toxin
K9D25_RS00390 (K9D25_00390) 88319..88558 - 240 WP_244378185.1 Arc family DNA-binding protein Antitoxin
K9D25_RS00395 (K9D25_00395) 88768..89826 + 1059 WP_244378186.1 quinolinate synthase NadA -
K9D25_RS00400 (K9D25_00400) 89865..91403 + 1539 WP_244378188.1 L-aspartate oxidase -
K9D25_RS00405 (K9D25_00405) 91579..92442 + 864 WP_244378189.1 carboxylating nicotinate-nucleotide diphosphorylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-126)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15011.10 Da        Isoelectric Point: 5.6501

>T216186 WP_279613767.1 NZ_CP083239:c88326-87901 [Ancylobacter polymorphus]
MNDHPRITNVVSEPMRPAGSPAVLDWLDRQAASTLFLTGTSLSELMLGAEILPAGRRREELRAGLAELLDTLFDSRILPF
DAAAAHAFARLVAQARSAGRAISVADGQIAAIATAHGFRVATRDRAPFEAAGVPVIDPWAE

Download         Length: 426 bp

>T216186 NZ_CP112996:c757444-757007 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8754.91 Da        Isoelectric Point: 9.0149

>AT216186 WP_244378185.1 NZ_CP083239:c88558-88319 [Ancylobacter polymorphus]
MSAVTIRNLPDEVHRALKDRAARHGRSTEAEIREILQAAVRPPERVKVGSALAAFGRRFNGIEFEPMRASDPAEPASFE

Download         Length: 240 bp

>AT216186 NZ_CP112996:c757695-757441 [Mycobacterium tuberculosis variant bovis]
ATGAGCATGCGTCTGGCGCATCGGCTCCAGATCCTGCTCGACGACGAGTGCCACCGCCGCATCACCGCGGTGGCGCGCGA
GCGAGGCGTCCCGGTCGCAACCGTCGTGCGTGAGGCCATTGATCGAGGCCTCGTCAGCCCCGCCGGTCGCCGCAAGTCCG
CGGGCAGGCGCCTGCTCGACGCCGCCGACATGTCCGTTCCCGAGCCGCGGGAGCTGAAGCAGGAACTCGAGGCCCTCCGG
GCGCGCCGCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References