Detailed information of TA system TA216183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): BrnTA/BrnT-BrnA
• Location: 4875..5460
• Replicon: plasmid unnamed
• Accession: NZ_CP083182
• Organism: Acinetobacter baumannii strain AB43

Toxin (Protein)

• Gene name: brnT
• Uniprot ID: -
• Locus tag: K9O37_RS18785
• Protein ID: WP_151204772.1
• Coordinates: 4875..5162 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: brnA
• Uniprot ID: -
• Locus tag: K9O37_RS18790
• Protein ID: WP_163078290.1
• Coordinates: 5149..5460 (+)
• Length: 104 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9O37_RS18770 (K9O37_18685)	691..1983	-	1293	WP_024436605.1	MFS transporter	-
K9O37_RS18775 (K9O37_18690)	2038..3276	-	1239	WP_005130394.1	M24 family metallopeptidase	-
K9O37_RS18780 (K9O37_18695)	3392..4351	-	960	WP_005130393.1	GlxA family transcriptional regulator	-
K9O37_RS18785 (K9O37_18700)	4875..5162	+	288	WP_151204772.1	BrnT family toxin	Toxin
K9O37_RS18790 (K9O37_18705)	5149..5460	+	312	WP_163078290.1	BrnA antitoxin family protein	Antitoxin
K9O37_RS18795 (K9O37_18710)	5529..6629	-	1101	WP_163078287.1	MBL fold metallo-hydrolase	-
K9O37_RS18800 (K9O37_18715)	6693..7442	+	750	WP_163078284.1	hypothetical protein	-
K9O37_RS18805 (K9O37_18720)	7813..8160	-	348	WP_004641894.1	hypothetical protein	-
K9O37_RS18810 (K9O37_18725)	8501..8761	-	261	WP_005000600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..104309	104309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (7-88)

Antitoxin

• BrnA antitoxin of type II toxin-antitoxin system (41-96)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11262.62 Da
• Isoelectric Point: 5.2063

>T216183 WP_151204772.1 NZ_CP083182:4875-5162 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDVSFETASLVFEDPLRISIQDRHTDGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNQYEHG

Nucleotide

• Length: 288 bp

>T216183 NZ_CP112996:c755039-754656 [Mycobacterium tuberculosis variant bovis]
TTGGCGGCTGCAACGACAACCGGAACCCACCGAGGCCTGGAACTCCGCGCTGCTCAGCGGGCCGTCGGGTCGTGCGAACC
GCAACGAGCCGAGTTCTGCCGATCAGCGCGGAATGCGGACGAGTTCGACCAGATGAGCCGGATGTTTGGTGACGTCTACC
CCGATGTGCCAGTGCCGAAATCCGTGTGGCGGTGGATCGATTCGGCACAGCACCGCCTCGCCCGGGCGGGAGCGGTGGGT
GCCCTGTCGGTTGTCGATCTGCTGATCTGCGACACTGCGGCGGCCAGGGGCCTAGTAGTCCTCCACGACGATGCCGACTA
CGAACTCGCAGAGCGTCACCTTCCCGACATCAGAGTGCGGAGGGTCGTCAGCGCCGACGACTAG

Antitoxin

Protein

• Length: 104 a.a.
• Molecular weight: 12033.69 Da
• Isoelectric Point: 8.4842

>AT216183 WP_163078290.1 NZ_CP083182:5149-5460 [Acinetobacter baumannii]
MSMVRYTRKELNENFSNKQDAEIERLLAKGTVPDDQLDLSDIPEITDWSNAIRHGQFYRPVKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLKDLKDH

Nucleotide

• Length: 312 bp

>AT216183 NZ_CP112996:c755289-755134 [Mycobacterium tuberculosis variant bovis]
GTGTCGGTGACCCAGATCGACCTCGACGACGAAGCGCTGGCCGATGTGATGCGCATCGCCGCCGTGCACACAAAGAAGGA
AGCCGTGAACCTCGCGATGCGCGATTACGTCGAACGGTTTCGGCGCATCGAGGCCCTGGCCCGCTCGCGCGAGTAG