216182

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 2650734..2652475 Replicon chromosome
Accession NZ_CP083181
Organism Acinetobacter baumannii strain AB43

Toxin (Protein)


Gene name pmenT Uniprot ID N9S537
Locus tag K9O37_RS13045 Protein ID WP_000233088.1
Coordinates 2651819..2652475 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID N9RUZ1
Locus tag K9O37_RS13040 Protein ID WP_004669001.1
Coordinates 2650734..2651819 (-) Length 362 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O37_RS13025 (K9O37_12975) 2647698..2648261 - 564 WP_001133235.1 TetR/AcrR family transcriptional regulator -
K9O37_RS13030 (K9O37_12980) 2648308..2648448 + 141 WP_000504068.1 hypothetical protein -
K9O37_RS13035 (K9O37_12985) 2649066..2649944 - 879 WP_000732870.1 MetQ/NlpA family ABC transporter substrate-binding protein -
K9O37_RS13040 (K9O37_12990) 2650734..2651819 - 1086 WP_004669001.1 macro domain-containing protein Antitoxin
K9O37_RS13045 (K9O37_12995) 2651819..2652475 - 657 WP_000233088.1 DUF4433 domain-containing protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(18-218)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25316.92 Da        Isoelectric Point: 7.1033

>T216182 WP_000233088.1 NZ_CP083181:c2652475-2651819 [Acinetobacter baumannii]
MVGRNYSDVLNPQKALIWRIVHRDNIPWILENGLHSSNSPTQCVNWVQIGSPELIEKRQLHPVPVGKKGVLSDYIPFYFT
PFSPMLLNIKSGRGGVRQRTNDEIVILVSSLYQLQQQQIPFVFTNSHAYYQWAEFYTDLSSLNEIDWSILQARDFKRDMD
DPAKFERYQAEALVHQHCPTKVLIGVICYTETVKAQIEQWLQQADVNIPVHVRQGVYF

Download         Length: 657 bp

>T216182 NZ_CP112996:719431-719838 [Mycobacterium tuberculosis variant bovis]
GTGAGCACGACGCCGGCCGCCGGAGTGCTCGACACGTCGGTGTTCATCGCGACCGAAAGCGGCCGGCAACTCGACGAGGC
GCTGATCCCCGACCGGGTCGCCACCACCGTCGTCACCCTCGCCGAACTGCGCGTCGGCGTGCTGGCCGCGGCGACGACCG
ACATCCGGGCTCAACGCCTGGCGACCCTGGAATCCGTTGCCGATATGGAAACGTTGCCCGTCGACGACGATGCCGCCCGA
ATGTGGGCCCGATTGCGGATCCATCTTGCCGAGTCCGGTCGCCGGGTGCGGATCAACGACCTGTGGATCGCGGCCGTCGC
GGCATCGCGAGCGCTGCCGGTCATCACCCAGGACGACGACTTCGCCGCCCTCGACGGTGCGGCCAGTGTGGAGATCATTC
GGGTCTGA

Antitoxin


Download         Length: 362 a.a.        Molecular weight: 41015.11 Da        Isoelectric Point: 5.8156

>AT216182 WP_004669001.1 NZ_CP083181:c2651819-2650734 [Acinetobacter baumannii]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPKNMAAYSQACKAGQVTTGKMFVTETNELMGARWIINFPTK
QHWRDKSKLQWIEDGLQDLKKFIIDHQVKSIAIPPLGAGNGGLEWSRVKSKIETELSDLEYVDILIFEPTTQYQNVAKKI
GVSQLTPARAMIAELVRRYWVLGIECSLLEIQKLAWFLQRVIEQKQLPNELKLNFQANYYGPYASNLDHLLNAMDGSYLK
SDKRIPDCDPLDVIWFNDQQKSKVQGYLISEAKEYMAAVEGAATLIEGFESPFGMELLATVDWLIYKEGYQPNVESIQEG
LANWSAGERWARRKSDLFKAEHIQFALQKLDGFAYSYSDVT

Download         Length: 1086 bp

>AT216182 NZ_CP112996:719174-719434 [Mycobacterium tuberculosis variant bovis]
ATGTCTGAGGTGGCCTCGCGTGAGCTGCGTAACGATACGGCCGGCGTGCTGCGCCGCGTGCGGGCAGGGGAGGACGTCAC
CATCACCGTCAGCGGCCGTCCGGTCGCGGTGCTTACCCCGGTTCGTCCGCGGCGCCGGCGTTGGCTGAGCAAAACGGAGT
TCCTGTCGCGGTTGCGCGGCGCTCAAGCCGATCCCGGGCTCCGTAACGACCTCGCGGTCCTTGCCGGCGACACGACCGAG
GATCTCGGGCCGATCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9S537

Antitoxin

Source ID Structure
AlphaFold DB N9RUZ1

References