Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 2178660..2179311 | Replicon | chromosome |
| Accession | NZ_CP083181 | ||
| Organism | Acinetobacter baumannii strain AB43 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A5Q0RPK1 |
| Locus tag | K9O37_RS10645 | Protein ID | WP_000838147.1 |
| Coordinates | 2179129..2179311 (-) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | L9LVK3 |
| Locus tag | K9O37_RS10640 | Protein ID | WP_002053018.1 |
| Coordinates | 2178660..2179064 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9O37_RS10625 (K9O37_10595) | 2173793..2173936 | - | 144 | WP_164523119.1 | hypothetical protein | - |
| K9O37_RS10630 (K9O37_10600) | 2173976..2177949 | - | 3974 | Protein_2074 | tape measure protein | - |
| K9O37_RS10635 (K9O37_10605) | 2178046..2178564 | - | 519 | WP_005070358.1 | DUF4468 domain-containing protein | - |
| K9O37_RS10640 (K9O37_10610) | 2178660..2179064 | - | 405 | WP_002053018.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K9O37_RS10645 (K9O37_10615) | 2179129..2179311 | - | 183 | WP_000838147.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K9O37_RS10650 (K9O37_10620) | 2179643..2180176 | - | 534 | WP_057691629.1 | hypothetical protein | - |
| K9O37_RS10655 (K9O37_10625) | 2180224..2181153 | - | 930 | WP_223673309.1 | phage tail tube protein | - |
| K9O37_RS10660 (K9O37_10630) | 2181262..2181474 | - | 213 | WP_030423712.1 | hypothetical protein | - |
| K9O37_RS10665 (K9O37_10635) | 2181476..2181874 | - | 399 | WP_030423713.1 | phage tail terminator-like protein | - |
| K9O37_RS10670 (K9O37_10640) | 2181876..2182244 | - | 369 | WP_025465131.1 | hypothetical protein | - |
| K9O37_RS10675 (K9O37_10645) | 2182210..2182620 | - | 411 | WP_223673310.1 | hypothetical protein | - |
| K9O37_RS10680 (K9O37_10650) | 2182727..2183500 | - | 774 | WP_223673311.1 | hypothetical protein | - |
| K9O37_RS10685 (K9O37_10655) | 2183479..2183847 | - | 369 | WP_223673392.1 | glutamate 5-kinase | - |
| K9O37_RS10690 (K9O37_10660) | 2183849..2184238 | - | 390 | WP_000008494.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | plc / plc | 1987987..2228502 | 240515 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6682.88 Da Isoelectric Point: 10.6602
>T216181 WP_000838147.1 NZ_CP083181:c2179311-2179129 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK
Download Length: 183 bp
>T216181 NZ_CP112996:717813-718208 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
ATGGTGATCGACACGTCCGCGCTCGTTGCGATGCTCAGCGACGAGCCAGACGCAGAGCGGTTCGAGGCCGCCGTCGAAGC
CGACCACATCCGGCTGATGTCGACGGCGTCTTACCTGGAAACGGCACTCGTGATAGAAGCCCGCTTCGGTGAACCGGGCG
GACGTGAGCTGGATCTGTGGCTTCATCGCGCCGCGGTCGACCTTGTTGCCGTGCATGCCGACCAAGCGGATGCCGCGCGC
GCCGCCTACCGCACGTACGGCAAGGGAAGGCATCGTGCGGGGCTCAACTACGGCGACTGCTTCTCATACGGCCTCGCCAA
GATCAGCGGCCAGCCACTCCTGTTCAAGGGCGAAGATTTCCAACACACCGACATCGCCACGGTCGCGCTGCCCTAA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14660.69 Da Isoelectric Point: 4.4289
>AT216181 WP_002053018.1 NZ_CP083181:c2179064-2178660 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT216181 NZ_CP112996:717559-717813 [Mycobacterium tuberculosis variant bovis]
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
ATGGCGCTGAGTATCAAGCACCCGGAAGCCGACCGGCTCGCGCGAGCGCTTGCGGCGCGCACCGGCGAGACGTTGACCGA
GGCAGTGGTTACCGCGTTGCGCGAGCGGCTCGCTCGTGAGACTGGGCGTGCCCGTGTTGTCCCGTTGCGCGACGAGCTTG
CCGCGATTCGGCACCGGTGCGCAGCGTTGCCGGTGGTCGACAACCGGTCCGCTGAGGCGATTCTCGGCTATGACGAGCGC
GGATTGCCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RPK1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5Q0RVR6 |