Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1937287..1938923 Replicon chromosome
Accession NZ_CP083181
Organism Acinetobacter baumannii strain AB43

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag K9O37_RS09435 Protein ID WP_114225260.1
Coordinates 1937592..1938923 (-) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag K9O37_RS09430 Protein ID WP_001101310.1
Coordinates 1937287..1937595 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O37_RS09405 (K9O37_09390) 1933778..1934182 - 405 Protein_1831 multidrug efflux RND transporter periplasmic adaptor subunit AdeA -
K9O37_RS09410 (K9O37_09395) 1934182..1934688 + 507 Protein_1832 SDR family NAD(P)-dependent oxidoreductase -
K9O37_RS09415 (K9O37_09400) 1934734..1935566 + 833 Protein_1833 SDR family NAD(P)-dependent oxidoreductase -
K9O37_RS09425 (K9O37_09405) 1935798..1936448 - 651 WP_230283172.1 IS3 family transposase -
K9O37_RS09430 (K9O37_09410) 1937287..1937595 - 309 WP_001101310.1 helix-turn-helix domain-containing protein Antitoxin
K9O37_RS09435 (K9O37_09415) 1937592..1938923 - 1332 WP_114225260.1 HipA domain-containing protein Toxin
K9O37_RS09440 (K9O37_09420) 1939218..1939658 + 441 WP_032018238.1 HD domain-containing protein -
K9O37_RS09445 (K9O37_09425) 1939788..1940720 + 933 WP_223673299.1 IS5-like element ISAba13 family transposase -
K9O37_RS09450 (K9O37_09430) 1940857..1941162 + 306 WP_000122230.1 IS630 transposase-related protein -
K9O37_RS09460 (K9O37_09440) 1942499..1942981 + 483 WP_223673300.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1935798..1942482 6684


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-359)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 51188.22 Da        Isoelectric Point: 4.8490

>T216180 WP_114225260.1 NZ_CP083181:c1938923-1937592 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T216180 NZ_CP083181:c1938923-1937592 [Acinetobacter baumannii]
ATGAAAAAATTAACGATACAAGCTTTACTAAATAAAAACTGGATAGATATAGCAGAGCTAAAACTGCTGGAACCTAAGTT
GGGTTCGGCTAGTGCCAGTGAACTAGAATATGAATTGGATTATGCCATTCAATATTTAGACAGACGAGATGAGCACGCCT
GTAGTTTATCACTTCCTGTACAAATTCTTATCAAACATGAATCGAACACATGGTTTGGCTTTTTAGATGATATTGTTCCA
TCTGGCGCTGCACGCCGTTATTGGGTGAATTATCTAGATTTACAACGCTTAACCTATGCGGAACAAGAAAGTATTCTATT
AGAAAAAGGTGGGATGGCACCTGTTGGTAATTTACGAATTAAAGAAGCATTGCCTCCACTAAACCCAGAGTCAACCTTGC
ACTTACGTTATTTTAGTAAGGAAGATGTAGCTGAGCGTAATATTGATTTTCTGGAATATGCTCAACAAATGGGAGCAATT
AGTGGTGGTGCAACTGGTGCAGGCGGTGAAGCTCCCAAGTTGCTTATTCGTGTTTCACCAGAACAAAAAGTCTGGATTGA
CACCTACCAAGAACAATTTGATCAGCCAGATCAGCATTATTTAGTTAAATTTCCGCGAAATAAACGTAGTGAGATTGATT
GCGATATTCTCAGAGCTGAATATTATTACTATCAAATACTCAATGAGTTAGGTTTCAATACGATAGAGACGACTCAAATG
CAGCTTATTGAAGGTACAAAATATCCGTCATTGTGGCTTCCAAGATTCGATACAGAATGGTGTGATCAATATTGGCACCG
CTATGGTCTAGAGTCTGTGTATTCTGTACTAAATAAGTCTTCTGGTAGTCATCTTAATCATTTCGAAGTCATTGAAGATC
TATGTAGATTACTCACAAGCATTGACTCAGATTTTGATGTACCACAATTTGTTTGTGAGTGGTTACAACGAGATTTACTC
AATATCATTTTTGGTAATTCAGATAACCATGGGCGTAATACATCGTTTATAAAAAAATCTGGAAAAATTTATCTTTCGCC
TATTTATGACTTTGCACCTATGAAAGCCGATCCAGAAGTTGTGACCAGATCGACGACTTGGGGAAGTCCGTACGAGGAAG
GTGGTGAATACCGGTGGGCGCAAATTACACAAAAACTTGCTCCTTGGTGCGATCCCGATTTATCTCTAGCAACATTAAGG
ACTTTGGCGAATAACCTGCTTGGCTTAAAGCAACGATTAGTTGATAAAGGTGTACCAAAACAAATTATTGAAATGCCAGC
GCTGTCATTTGATTACATAGAAGCTAAATTGAAAAGATGGGAACTGCTATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11630.54 Da        Isoelectric Point: 9.9701

>AT216180 WP_001101310.1 NZ_CP083181:c1937595-1937287 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Download         Length: 309 bp

>AT216180 NZ_CP083181:c1937595-1937287 [Acinetobacter baumannii]
ATGAATGTAAAAAATCAAACCCAAGACCGTCAGCAGATTCTTATAGATTTATATAAACAATATTTGTTGAGTGAGATTAC
TTTGGGGCAATTGCTATCGTATTTACGCAAAAATGTGTTGGGTTTATCGCAAGAACAATATGCTAATTTGGTGGGTATAA
GCCGTCGGACTTTAACGGACATTGAGCAGGATAAAGGTAAACTCACTCAGTCTGTGTTAGATAAAGTGTTTAAACCACTT
GGTTTAAAAGCAGGGCTTGTACCTACGCATGAACATATTGTTAGCAAAATTATAAAGCCAAACGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References