Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 484720..485373 Replicon chromosome
Accession NZ_CP083181
Organism Acinetobacter baumannii strain AB43

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J8TGE7
Locus tag K9O37_RS02360 Protein ID WP_024437032.1
Coordinates 484984..485373 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V5V966
Locus tag K9O37_RS02355 Protein ID WP_001288210.1
Coordinates 484720..484977 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O37_RS02335 (K9O37_02335) 480236..481243 + 1008 WP_000198631.1 DNA-directed RNA polymerase subunit alpha -
K9O37_RS02340 (K9O37_02340) 481262..481639 + 378 WP_001216380.1 50S ribosomal protein L17 -
K9O37_RS02345 (K9O37_02345) 481821..483311 + 1491 WP_000415132.1 NAD(P)/FAD-dependent oxidoreductase -
K9O37_RS02350 (K9O37_02350) 483360..484532 - 1173 WP_017725189.1 acyl-CoA dehydrogenase family protein -
K9O37_RS02355 (K9O37_02355) 484720..484977 + 258 WP_001288210.1 succinate dehydrogenase assembly factor 2 Antitoxin
K9O37_RS02360 (K9O37_02360) 484984..485373 + 390 WP_024437032.1 membrane protein Toxin
K9O37_RS02365 (K9O37_02365) 486143..487228 + 1086 WP_000049106.1 hypothetical protein -
K9O37_RS02370 (K9O37_02370) 487306..487872 + 567 WP_000651536.1 rhombosortase -
K9O37_RS02375 (K9O37_02375) 488060..490255 + 2196 WP_001158905.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15584.82 Da        Isoelectric Point: 10.3889

>T216179 WP_024437032.1 NZ_CP083181:484984-485373 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAALFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYQSQNTV
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T216179 NZ_CP112996:704634-705035 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGACACGTCGGCGATCATCGCGATTCTGCGCGACGAGGACGACGCCGCGGCCTACGCCGACGCGCTCGCCAA
CGCCGATGTCCGCAGACTGTCTGCGGCCAGCTACCTGGAATGCGGGATAGTCCTTGACTCCCAGCGTGATCCGGTCATCA
GCAGAGCACTGGATGAACTTATCGAAGAAGCCGAGTTCGTCGTCGAGCCGGTAACCGAGCGCCAGGCCCGCCTGGCCCGA
GCGGCCTACGCGGATTTCGGCAGAGGCAGCGGCCACCCCGCGGGCTTGAATTTCGGCGACTGCCTGTCCTATGCACTGGC
GATCGATCGACGTGAGCCGCTGCTGTGGAAGGGCAACGACTTTGGGCACACCGGCGTCCAAAGGGCACTGGATCGGCGGT
GA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10318.77 Da        Isoelectric Point: 4.6150

>AT216179 WP_001288210.1 NZ_CP083181:484720-484977 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT216179 NZ_CP112996:704392-704637 [Mycobacterium tuberculosis variant bovis]
ATGGCGTTGAACATCAAAGATCCGTCGGTTCACCAGGCGGTCAAGCAGATCGCGAAAATCACCGGCGAATCTCAGGCTCG
GGCGGTGGCGACCGCGGTGAACGAGCGTCTGGCCAGACTGCGCAGCGACGATCTCGCCGCCCGGCTCTTGGCTATCGGCC
ACAAGACCGCGAGCAGGATGAGCCCGGAAGCAAAGCGCCTCGACCACGATGCTCTGCTGTATGACGAGCGAGGGCTGCCG
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TGE7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BQM7

References