Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) abiEi-abiEii/AbiEii-AbiEi
Location 1127913..1129345 Replicon chromosome
Accession NZ_CP083177
Organism Gardnerella vaginalis strain JNFY1

Toxin (Protein)


Gene name abiEi Uniprot ID -
Locus tag K9E36_RS04530 Protein ID WP_116437936.1
Coordinates 1127913..1128758 (-) Length 282 a.a.

Antitoxin (Protein)


Gene name abiEii Uniprot ID -
Locus tag K9E36_RS04535 Protein ID WP_248911440.1
Coordinates 1128755..1129345 (-) Length 197 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9E36_RS04500 (K9E36_04515) 1123016..1123477 + 462 WP_004114257.1 hypothetical protein -
K9E36_RS04505 (K9E36_04520) 1123512..1124165 + 654 WP_004114259.1 response regulator transcription factor -
K9E36_RS04510 (K9E36_04525) 1124200..1125372 + 1173 WP_116437934.1 exodeoxyribonuclease V -
K9E36_RS04515 (K9E36_04530) 1125731..1127182 + 1452 WP_116437935.1 ATP-binding protein -
K9E36_RS04520 (K9E36_04535) 1127288..1127461 - 174 WP_004110365.1 hypothetical protein -
K9E36_RS04525 (K9E36_04540) 1127458..1127751 - 294 WP_016635756.1 DUF2089 family protein -
K9E36_RS04530 (K9E36_04545) 1127913..1128758 - 846 WP_116437936.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
K9E36_RS04535 (K9E36_04550) 1128755..1129345 - 591 WP_248911440.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
K9E36_RS04540 (K9E36_04555) 1129607..1130701 - 1095 WP_004114270.1 class 1b ribonucleoside-diphosphate reductase subunit beta -
K9E36_RS04545 (K9E36_04560) 1130785..1132989 - 2205 WP_162861397.1 class 1b ribonucleoside-diphosphate reductase subunit alpha -
K9E36_RS04550 (K9E36_04565) 1133103..1133597 - 495 WP_004116137.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
K9E36_RS04555 (K9E36_04570) 1133666..1133917 - 252 WP_004114274.1 glutaredoxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1118329..1141981 23652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-262)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-51)


Sequences

Toxin        


Download         Length: 282 a.a.        Molecular weight: 32612.37 Da        Isoelectric Point: 8.1852

>T216175 WP_116437936.1 NZ_CP083177:c1128758-1127913 [Gardnerella vaginalis]
VNKAKLTALCHKMSAKTGLTFNSVMIYYFLEVILKKLSQSNYSDHYVFKGGFLLSNIIGINSRSTVDIDFQFHKMELSKE
KVKKQLTEVFANSKDDISFSIQSITAIKESDDYGGYRATILCELENIKQVVHLDIATGDVVTPQPINYYYKAIFTDETFP
IIAYNVESILAEKLQTIYSRNFLNSRSKDFYDIFILLKLKKDDIDFSQLKIACQRTFLYRETELDFNKIIKLLESFKTDY
TQNQQWQNYSKKYSYTKGITFSNVLDETINLLNILSAKQND

Download         Length: 846 bp

>T216175 NZ_CP112996:c445851-445258 [Mycobacterium tuberculosis variant bovis]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGG
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGATCGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin


Download         Length: 197 a.a.        Molecular weight: 23059.41 Da        Isoelectric Point: 8.7502

>AT216175 WP_248911440.1 NZ_CP083177:c1129345-1128755 [Gardnerella vaginalis]
MSNKEMLLDYLDNHHGIITYKDCKTLNIPTIYLTRLKNEGVINRIERGIFLSSNGDYDEYYFFQYRYPQAVFSYVSALYL
QGFTDEIPQHFEVSVPRGYRFNNPPSNLTIHWVSKLYSKLGITTTITTMGNKVRVYDFERIICDFIINRNSIDSELFVKT
LQAYSRYNGKDLIKLHEYATKMNISNKVKQTLEVLL

Download         Length: 591 bp

>AT216175 NZ_CP112996:c446269-445880 [Mycobacterium tuberculosis variant bovis]
GTGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGACGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References