Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-HTH_19
Location 960127..961428 Replicon chromosome
Accession NZ_CP083171
Organism Gardnerella vaginalis strain JNFY14

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag K9E42_RS03900 Protein ID WP_248898497.1
Coordinates 960127..960936 (-) Length 270 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag K9E42_RS03905 Protein ID WP_248898498.1
Coordinates 960955..961428 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9E42_RS03880 (K9E42_03895) 956032..956769 + 738 WP_116437048.1 thiamine diphosphokinase -
K9E42_RS03885 (K9E42_03900) 956945..958000 + 1056 WP_004112995.1 type I glyceraldehyde-3-phosphate dehydrogenase -
K9E42_RS03890 (K9E42_03905) 958110..958610 + 501 WP_004112997.1 Cys-tRNA(Pro) deacylase -
K9E42_RS03895 (K9E42_03910) 958658..959617 + 960 WP_004114532.1 aldose 1-epimerase family protein -
K9E42_RS03900 (K9E42_03915) 960127..960936 - 810 WP_248898497.1 zeta toxin family protein Toxin
K9E42_RS03905 (K9E42_03920) 960955..961428 - 474 WP_248898498.1 helix-turn-helix transcriptional regulator Antitoxin
K9E42_RS03910 (K9E42_03925) 961945..963321 - 1377 WP_248898499.1 hypothetical protein -
K9E42_RS03915 (K9E42_03930) 964181..965191 + 1011 WP_004116755.1 UDP-glucose 4-epimerase GalE -
K9E42_RS03920 (K9E42_03935) 965430..965753 - 324 WP_004138646.1 hypothetical protein -
K9E42_RS03925 (K9E42_03940) 965839..965994 + 156 WP_248898500.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(34-221)

Antitoxin

Cro/C1-type helix-turn-helix domain

(6-59)


Sequences

Toxin        


Download         Length: 270 a.a.        Molecular weight: 30907.81 Da        Isoelectric Point: 9.1594

>T216170 WP_248898497.1 NZ_CP083171:c960936-960127 [Gardnerella vaginalis]
MGKCDFAMVIEDFSEEYFTHCLLRNLRSLQMYKHADLHPKAVLLGCQSGAGKTTIHVIKQKEFNGNIIILDADSYRTQHP
YYCELLDKYGKESVKYTSAFSAKMVRSLIDELSSKKYNLIIEGTLRSVEVPSSTAKMLIDRGYRVSLAVIATKPELSWIS
TLIRYREMYLEDPKSARATPKDHHDNIVNNIVDNLLKLEKSKIFGRIQIYKRDEKCIYDSDSYKNSPNITVASVLKEVLF
GKKTIDEKKLICHAKNRLNELDKLIDKSL

Download         Length: 810 bp

>T216170 NZ_CP112981:c66725-65400 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 18043.55 Da        Isoelectric Point: 5.9593

>AT216170 WP_248898498.1 NZ_CP083171:c961428-960955 [Gardnerella vaginalis]
MVSVNIRALRRSKKLTQQELAEVLGVSRNSIVRYENGTSAISTRLIDKICNKFKVSLFDIVHEKELSASDKYDLNMKIEV
LKERGALLLARLYKYEDSMNIQFDDSSNAWIAISDDLSDVINTKIYTSTNFEDINRYIGYLDGIERLLEYVSCNKNS

Download         Length: 474 bp

>AT216170 NZ_CP112981:c67023-66730 [Enterobacter hormaechei subsp. xiangfangensis]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References