Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4222232..4222851 Replicon chromosome
Accession NZ_CP083075
Organism Klebsiella pneumoniae strain 0113481141

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F42_RS21035 Protein ID WP_002892050.1
Coordinates 4222633..4222851 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F42_RS21030 Protein ID WP_002892066.1
Coordinates 4222232..4222606 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F42_RS21020 (4217384) 4217384..4218577 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F42_RS21025 (4218600) 4218600..4221746 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F42_RS21030 (4222232) 4222232..4222606 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F42_RS21035 (4222633) 4222633..4222851 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F42_RS21040 (4223014) 4223014..4223580 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F42_RS21045 (4223552) 4223552..4223692 - 141 WP_004147370.1 hypothetical protein -
K9F42_RS21050 (4223713) 4223713..4224183 + 471 WP_020802585.1 YlaC family protein -
K9F42_RS21055 (4224158) 4224158..4225609 - 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
K9F42_RS21060 (4225710) 4225710..4226408 + 699 WP_023287311.1 GNAT family protein -
K9F42_RS21065 (4226405) 4226405..4226545 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F42_RS21070 (4226545) 4226545..4226808 - 264 WP_032432663.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216140 WP_002892050.1 NZ_CP083075:4222633-4222851 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216140 NZ_CP112891:c1269911-1269597 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216140 WP_002892066.1 NZ_CP083075:4222232-4222606 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216140 NZ_CP112891:c1269600-1269310 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References