Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1568710..1569353 Replicon chromosome
Accession NZ_CP083075
Organism Klebsiella pneumoniae strain 0113481141

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag K9F42_RS07770 Protein ID WP_032433387.1
Coordinates 1568937..1569353 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag K9F42_RS07765 Protein ID WP_001261276.1
Coordinates 1568710..1568940 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F42_RS07750 (1563732) 1563732..1564819 + 1088 Protein_1517 transcriptional regulator -
K9F42_RS07755 (1564822) 1564822..1567062 + 2241 WP_045326788.1 P-loop NTPase fold protein -
K9F42_RS07760 (1567590) 1567590..1568405 - 816 WP_032433388.1 hypothetical protein -
K9F42_RS07765 (1568710) 1568710..1568940 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K9F42_RS07770 (1568937) 1568937..1569353 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
K9F42_RS07775 (1569509) 1569509..1570489 + 981 WP_032433385.1 hypothetical protein -
K9F42_RS07780 (1570684) 1570684..1572255 - 1572 WP_032433383.1 AAA family ATPase -
K9F42_RS07785 (1572574) 1572574..1572822 + 249 WP_032433382.1 hypothetical protein -
K9F42_RS07790 (1572881) 1572881..1573399 + 519 WP_045326794.1 hypothetical protein -
K9F42_RS07795 (1573430) 1573430..1573921 + 492 WP_032433378.1 hypothetical protein -
K9F42_RS07800 (1573981) 1573981..1574184 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T216129 WP_032433387.1 NZ_CP083075:1568937-1569353 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T216129 NZ_CP112887:c1019537-1019196 [Raoultella electrica]
ATGTGGGACATAGAAACTACGGATGCTTTCGATGAGTGGTTTGAAGCGCAAACGGGTGCACTGCAGGAAGACATGCTGGC
CGCTATGGTGATTTTATCCGAGTATGGCCCACAGTTAGGCAGACCGTTTGCAGATACCGTGAATGATTCTGCTTTTCCGA
ACATGAAAGAATTGCGCGTACAGCATCAAGGTAATCCAATCCGGGCCTTCTTTGCGTTTGATCCTTCCCGCCATGGCATC
GTGCTATGTGCCGGGGACAAAACGGGATTAAGCGAAAAAAGATTCTACAGAGACATGCTCAGGCTTGCCGATAATGAATA
CCGTAACCATCTGAATAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT216129 WP_001261276.1 NZ_CP083075:1568710-1568940 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT216129 NZ_CP112887:c1019186-1018887 [Raoultella electrica]
ATGTCCACTCTTAAAGAGCTTATGGCTAAGCAAAACCCAGAAAGCCGGGAGCGTATTGCCGAAAAAGTGGAAGAACTTCG
CCAGACGATCGCTTTGAATATGCTGAGGGAAGAGCTGAATATTTCTCAAACGGAGCTGGCGGCAGCGATGGGCGTTAAGC
AGCCAACGGTAGCAAAAATAGAGCAGGCGGATAACGATCCCCGCCTGTCGACCCTGAAACGTTACGTCACTGCTCTCGGC
GGCGAGCTCAGTATCGACGTGAAGCTCCCGACAGGTAAAAGGGTCGCATTCCACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References