Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 949504..950161 Replicon chromosome
Accession NZ_CP083075
Organism Klebsiella pneumoniae strain 0113481141

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F42_RS04785 Protein ID WP_002916310.1
Coordinates 949751..950161 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F42_RS04780 Protein ID WP_002916312.1
Coordinates 949504..949770 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F42_RS04755 (944660) 944660..946093 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
K9F42_RS04760 (946212) 946212..946940 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F42_RS04765 (946990) 946990..947301 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F42_RS04770 (947465) 947465..948124 + 660 WP_002916317.1 hemolysin III family protein -
K9F42_RS04775 (948275) 948275..949258 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F42_RS04780 (949504) 949504..949770 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F42_RS04785 (949751) 949751..950161 + 411 WP_002916310.1 protein YgfX Toxin
K9F42_RS04790 (950168) 950168..950689 - 522 WP_004144730.1 flavodoxin FldB -
K9F42_RS04795 (950790) 950790..951686 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F42_RS04800 (951709) 951709..952422 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F42_RS04805 (952428) 952428..954161 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T216128 WP_002916310.1 NZ_CP083075:949751-950161 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216128 NZ_CP112887:818163-818573 [Raoultella electrica]
GTGGTCCTGTGGCAATCTGATTTACGCATTTCCTGGCGTTCACAGTGGTTCTCGCTGCTGCTACATGGCGTTGTGGCGGC
TATTGTGCTGCTGATGCCGTGGCCGCTGAGCTACACACCGCTTTGGCTACTGCTGCTGTCGCTGGTGGTGTTCGACAGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCGGGGGGAAATAAAGCTGATGACCGATTCGCGTTTGCGTTGGCAAAAAGCG
GAATGGGAGATTGTCGGCACGCCGTGGGTGATTAATAGCGGGATGTTGCTGCGCCTGCAGGATATGCAAACACGCCGCCG
CCAGCATCTGTGGGTCGCTGCAGACAGTATGGATGCCAGAGAGTGGCGAGATCTGCGCCGGTTGGTGTTACAAAAACCGG
CACAGGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216128 WP_002916312.1 NZ_CP083075:949504-949770 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216128 NZ_CP112887:817916-818182 [Raoultella electrica]
ATGGACATTACGAATAAAGCCCGCATCCACTGGGCATGCCGCCGGGGTATGCGTGAACTTGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGATACGCTCAGCGATGAAGACAAACAGCTGTTCATCCGCCTGTTAGAAAACGACGATCCGGATC
TGTTTAACTGGCTGATGAATCATGGCGAACCGGCTGATGCGCAACTGCAACGGATGGTAAAATTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References