Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 31218..32128 Replicon plasmid p1-1230_0791_KP
Accession NZ_CP083071
Organism Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag K9F20_RS26265 Protein ID WP_004026354.1
Coordinates 31658..32128 (+) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A2J4RLY9
Locus tag K9F20_RS26260 Protein ID WP_004181895.1
Coordinates 31218..31661 (+) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F20_RS26245 (K9F20_26175) 26841..27872 + 1032 WP_029505552.1 hypothetical protein -
K9F20_RS26250 (K9F20_26180) 29424..29846 + 423 WP_004181893.1 translesion error-prone DNA polymerase V autoproteolytic subunit -
K9F20_RS26255 (K9F20_26185) 29846..31117 + 1272 WP_004181894.1 translesion error-prone DNA polymerase V subunit UmuC -
K9F20_RS26260 (K9F20_26190) 31218..31661 + 444 WP_004181895.1 DUF2384 domain-containing protein Antitoxin
K9F20_RS26265 (K9F20_26195) 31658..32128 + 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
K9F20_RS26270 (K9F20_26200) 32238..32498 - 261 WP_004026352.1 hypothetical protein -
K9F20_RS26275 (K9F20_26205) 33221..33379 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K9F20_RS26280 (K9F20_26210) 33982..34956 + 975 WP_014386572.1 hypothetical protein -
K9F20_RS26285 (K9F20_26215) 35154..35531 - 378 WP_004181901.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..202875 202875


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T216124 WP_004026354.1 NZ_CP083071:31658-32128 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T216124 NZ_CP112880:5480233-5480580 [Streptomyces sp. CA-278952]
ATGAGGCGCGGTGACATCTATCTGGTCGACTACGAGCCGGTGCGGGACAGCGAGGCCAACAAGGCGCGTCCCTCGATCAT
CGTCTCCAATGATGGTGCGAACGCCGCGGTGGACCGGGCGGGACGCGGCGTGGTCACCGTGGTGCCGCTGACGTCGAACG
TCTCTCGCCTCTACCCCTTCCAGGTGCTTCTCCAAGCGGGCGATTCCGGCCTGGCGAAGGACTCCAAGGTGCAGTGCGAG
CAGGTACGGGCGATGGCTCAGGAGCGGTTCGTGCGGCAGATCGGCCGGGTCCCCCGCCAGCGCATGGCCGAGATCGACGC
GGCCCTCCGCCGCCATCTCGCGCTCTGA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16536.87 Da        Isoelectric Point: 10.3013

>AT216124 WP_004181895.1 NZ_CP083071:31218-31661 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT216124 NZ_CP112880:5480016-5480246 [Streptomyces sp. CA-278952]
ATGAAGATCAGTGTGAGTCTGCCGCAGGAGGATGTCGCCTTCGTCGACGAGTACGCGACGAAGACCGAAGCGGATTCCCG
GTCCGCCGTCATACACGCCGCCATCGAGCTGTTGCGAGCCTCGAATCTTGAGGCCGACTACGTGGCGGCTTTCGCCGAAT
GGGATGAGAGCGAGGACGCCGCGTTCTGGGACAAGTTCTCGGGGGACGGGATCGTCGATGAGGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4RLY9

References