Detailed information of TA system TA216122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4907146..4908827
• Replicon: chromosome
• Accession: NZ_CP083070
• Organism: Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: K9F20_RS24095
• Protein ID: WP_015959269.1
• Coordinates: 4907146..4908021 (-)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: K9F20_RS24100
• Protein ID: WP_004177809.1
• Coordinates: 4908069..4908827 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F20_RS24075 (4902452)	4902452..4903972	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
K9F20_RS24080 (4903969)	4903969..4904967	+	999	WP_002885172.1	ribose ABC transporter permease	-
K9F20_RS24085 (4904998)	4904998..4905939	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
K9F20_RS24090 (4906014)	4906014..4907021	+	1008	WP_015959270.1	carbohydrate kinase family protein	-
K9F20_RS24095 (4907146)	4907146..4908021	-	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K9F20_RS24100 (4908069)	4908069..4908827	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
K9F20_RS24105 (4908913)	4908913..4909641	-	729	WP_032413197.1	response regulator transcription factor	-
K9F20_RS24110 (4909914)	4909914..4912061	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
K9F20_RS24115 (4912058)	4912058..4912201	-	144	WP_162897205.1	hypothetical protein	-
K9F20_RS24120 (4912523)	4912523..4913209	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T216122 WP_015959269.1 NZ_CP083070:c4908021-4907146 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T216122 NZ_CP112880:c4823811-4823551 [Streptomyces sp. CA-278952]
GTGAAGTTCGTGTGGGACCAGTCGTCCTGGGACGACTACGTTTGGTGGCAGAACCAGGATCGCAAGATCCTCAAGAGGAT
CAACACACTGCTCCAGGACATCGCCCGCAACGGCAACGAGGGAATGGGAAAGCCGGAGCCCCTGAAGCACGGCTTCCAGG
GCTACTGGTCCCGGCGCATCACCGACGAGCACCGGCTCATCTACACGGTCGCCGGCGACGAGGTCCGTATCGCCGCCTGC
CGCTACCACTACGGCCGGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT216122 WP_004177809.1 NZ_CP083070:c4908827-4908069 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT216122 NZ_CP112880:c4824059-4823808 [Streptomyces sp. CA-278952]
ATGCGCACGATGACCTACACCGAGTCCCGCGCGAAGTACGCCGAGACCCTGAGCGCCGTCGTGGACGACCGCGAGGAGGT
CGTGGTCACGCGCGCCGGGCATGAGCCCGTGGTGATAGTGGCGCTCGATGAGTACGAGTCCCTCAAAGAGACCGCGTACC
AGCTGCGGAGCCCGGAGAACGCCCGCCGCCTGCTGGCCTCGATCGACCGCCTGGAGAACGGCGGCGGCACGGTGCGGGAG
CTCGCGGAGTGA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05