Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2668499..2670087 Replicon chromosome
Accession NZ_CP083070
Organism Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)


Gene name hipA Uniprot ID W8UI36
Locus tag K9F20_RS13245 Protein ID WP_002904792.1
Coordinates 2668499..2669821 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag K9F20_RS13250 Protein ID WP_002904790.1
Coordinates 2669821..2670087 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F20_RS13230 (2663555) 2663555..2666056 + 2502 WP_032433099.1 fimbria/pilus outer membrane usher protein -
K9F20_RS13235 (2666044) 2666044..2667048 + 1005 WP_032433097.1 fimbrial protein -
K9F20_RS13240 (2667190) 2667190..2668482 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
K9F20_RS13245 (2668499) 2668499..2669821 - 1323 WP_002904792.1 type II toxin-antitoxin system HipA family toxin Toxin
K9F20_RS13250 (2669821) 2669821..2670087 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
K9F20_RS13255 (2670473) 2670473..2670799 - 327 WP_002904788.1 hydroxyisourate hydrolase -
K9F20_RS13260 (2670796) 2670796..2671296 - 501 WP_032433095.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
K9F20_RS13265 (2671274) 2671274..2672653 - 1380 WP_032433093.1 nucleobase:cation symporter-2 family protein -
K9F20_RS13270 (2672999) 2672999..2674153 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
K9F20_RS13275 (2674134) 2674134..2675057 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T216118 WP_002904792.1 NZ_CP083070:c2669821-2668499 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T216118 NZ_CP112876:207146-207400 [Pseudanabaena galeata CCNP1313]
GTGACGGTTATTTTTGATGATGATGCTTGGGAAGATTATCTCTATTGGCAGCGTACCGATCCAAAGGTTTTAAAACGGAT
TAATGCTTTGATTAAGGAGATTCAGCGTAGTCCCTATGAGGGTGTTGGTAAGCCTGAGCCTCTGAAATATAATTTTGCTG
GCTATTGGTCAAGGCGGATCAATGATGAGCATCGGCTTGTTTATCAGGTAAATGATAACGATGTGCTGATTGCTCAACTT
CGATATCACTATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT216118 WP_002904790.1 NZ_CP083070:c2670087-2669821 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT216118 NZ_CP112876:206898-207149 [Pseudanabaena galeata CCNP1313]
ATGAATGCAGTTACATATACCCATGTCCGCAATAACTTAGCAACGATGATGGATCAGGTATGTGCTGATCACACGCCTGT
GATCGTGACGCGCCAAAATCAGCAACCTGTGATCATGCTGTCTTTAGAAGACTACGAATCTTTGGTGGAAACTGCCTATT
TGTTGCGTAGCCCTAAGAATGCAGAGAGATTAACTAAGGCGATCGCTCGACTAAATGCTGGTGAGGGACAGGTGCGGGAG
TTGATCGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CEC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References