Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2928973..2929593 Replicon chromosome
Accession NC_008150
Organism Yersinia pestis Antiqua

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag YPA_RS13725 Protein ID WP_002208622.1
Coordinates 2929390..2929593 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag YPA_RS13720 Protein ID WP_002218472.1
Coordinates 2928973..2929341 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPA_RS13705 2927168..2927428 + 261 WP_002208617.1 type B 50S ribosomal protein L31 -
YPA_RS13710 2927444..2927587 + 144 WP_002208618.1 type B 50S ribosomal protein L36 -
YPA_RS13715 2928461..2928814 + 354 WP_002208619.1 hypothetical protein -
YPA_RS13720 2928973..2929341 + 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
YPA_RS13725 2929390..2929593 + 204 WP_002208622.1 expression modulating protein YmoA Toxin
YPA_RS13730 2930481..2930870 + 390 WP_002208623.1 MGMT family protein -
YPA_RS13735 2931006..2931527 - 522 WP_002208624.1 lipoprotein -
YPA_RS13740 2931784..2932644 + 861 WP_002208625.1 acyl-CoA thioesterase II -
YPA_RS13745 2932904..2934193 - 1290 WP_011566312.1 ammonium transporter AmtB -
YPA_RS13750 2934233..2934571 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T21611 WP_002208622.1 NC_008150:2929390-2929593 [Yersinia pestis Antiqua]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T21611 NC_008150:2929390-2929593 [Yersinia pestis Antiqua]
ATGACAAAAACTGACTACCTGATGCGTTTAAGAAAATGTACGACTATCGATACGCTAGAACGTGTAATTGAAAAAAATAA
GTACGAACTTTCTGATGATGAACTGGAATTGTTTTACTCAGCTGCAGACCATCGCCTGGCTGAACTAACGATGAATAAGC
TTTATGATAAAATTCCACCTACTGTATGGCAACATGTGAAATAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT21611 WP_002218472.1 NC_008150:2928973-2929341 [Yersinia pestis Antiqua]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT21611 NC_008150:2928973-2929341 [Yersinia pestis Antiqua]
ATGGATGAGTACTCGCCTAAGCGGCATGACATTGCCCAACTGAAGTTTCTATGTGAAAGCTTGTATGATGAAGGTATTGC
AACTCTTGGCGACAGCCATCATGGCTGGATAAATGACCCAACGTCGGCCATAAACCTTCAACTCAATGATTTGATCGAGC
ATATAGCTTCATTTGTGATGAGTTTTAAAATAAAATACCCGGATGGAAGCCAGCTTTCCGAGTTAGTGGAAGAATATTTA
GACGACACATATACTCTGTTTAGTAGTTATGGAATCAATGATCCTGAATTGCGTCGCTGGCAGAAAACCAAAGAGCATTT
ATTCAGACTTTTCTCAGGGGAATACGTATGTACCCTGATGAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References