Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1456116..1456759 Replicon chromosome
Accession NZ_CP083070
Organism Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)


Gene name vagD Uniprot ID A0A4S8C081
Locus tag K9F20_RS07180 Protein ID WP_032433387.1
Coordinates 1456343..1456759 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag K9F20_RS07175 Protein ID WP_001261276.1
Coordinates 1456116..1456346 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F20_RS07160 (1451138) 1451138..1452225 + 1088 Protein_1399 transcriptional regulator -
K9F20_RS07165 (1452228) 1452228..1454468 + 2241 WP_045326788.1 P-loop NTPase fold protein -
K9F20_RS07170 (1454996) 1454996..1455811 - 816 WP_032433388.1 hypothetical protein -
K9F20_RS07175 (1456116) 1456116..1456346 + 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
K9F20_RS07180 (1456343) 1456343..1456759 + 417 WP_032433387.1 type II toxin-antitoxin system VapC family toxin Toxin
K9F20_RS07185 (1456915) 1456915..1457895 + 981 WP_032433385.1 hypothetical protein -
K9F20_RS07190 (1458090) 1458090..1459661 - 1572 WP_032433383.1 AAA family ATPase -
K9F20_RS07195 (1459980) 1459980..1460228 + 249 WP_032433382.1 hypothetical protein -
K9F20_RS07200 (1460287) 1460287..1460805 + 519 WP_045326794.1 hypothetical protein -
K9F20_RS07205 (1460836) 1460836..1461327 + 492 WP_032433378.1 hypothetical protein -
K9F20_RS07210 (1461387) 1461387..1461590 + 204 WP_032433376.1 HHA domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1439975..1484486 44511


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14974.43 Da        Isoelectric Point: 7.8921

>T216108 WP_032433387.1 NZ_CP083070:1456343-1456759 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALHLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFARVPGLTLEDWVI

Download         Length: 417 bp

>T216108 NZ_CP112874:c3475431-3475138 [Pseudanabaena galeata CCNP1313]
ATGGCTATCACCACTACTCGATGGAACTCAGCAGAACATCTAAAAACAGAAGAAGATATTCAATTATATTTGGAAGCTTG
TCTTGAAGAAGCAGGTGATGCTCCTAACGTGATCATCCATGCATTTAGTGTTATCGCTCGCGCCAAGAACATGACTCAGT
TAGCAAAAGAATCAGGCTTAACAAGAGAGGGGCTATACAAGGCATTATCCCCTGATGGTAATCCTAGTTTTGCGACAGTG
ACAAAAGTTGCTAAAGCGCTTGGATATAAGCTGACCGTCCAGCCAGTTATTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT216108 WP_001261276.1 NZ_CP083070:1456116-1456346 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT216108 NZ_CP112874:c3475728-3475435 [Pseudanabaena galeata CCNP1313]
ATTGAAGTTCGCCAGACAGAAATATTCGTCAACTGGTTTGTCAAATTAAGAGACAAAAAAGCCAAAGCCCGCATACAAGC
CCGTATCGATCGCATGGAAATGGGAAACTTTGGTGATGTTGCTCCAGTTGGACAAGGAGTAAGCGAAATGCGAATATTTT
ACGGCACTGGCTATAGAGTGTATTTTGTGCAGAGAGGTTCAATCCTTGTGATACTTCTATGTGGCGGCGATAAAAGCACT
CAGACTTCTGACATAAATAAAGCTAAGGAACTAGTTAAACAATTGGAGGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S8C081

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References