Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 837185..837842 Replicon chromosome
Accession NZ_CP083070
Organism Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F20_RS04195 Protein ID WP_002916310.1
Coordinates 837432..837842 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F20_RS04190 Protein ID WP_002916312.1
Coordinates 837185..837451 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F20_RS04165 (832341) 832341..833774 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
K9F20_RS04170 (833893) 833893..834621 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F20_RS04175 (834671) 834671..834982 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F20_RS04180 (835146) 835146..835805 + 660 WP_002916317.1 hemolysin III family protein -
K9F20_RS04185 (835956) 835956..836939 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
K9F20_RS04190 (837185) 837185..837451 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F20_RS04195 (837432) 837432..837842 + 411 WP_002916310.1 protein YgfX Toxin
K9F20_RS04200 (837849) 837849..838370 - 522 WP_004144730.1 flavodoxin FldB -
K9F20_RS04205 (838471) 838471..839367 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F20_RS04210 (839390) 839390..840103 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F20_RS04215 (840109) 840109..841842 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T216107 WP_002916310.1 NZ_CP083070:837432-837842 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216107 NZ_CP112874:3453410-3453781 [Pseudanabaena galeata CCNP1313]
GTGAGTAGTTTATTTTTGAAGCCTGTTGAATGGATTGGAAGTTCTCTAGATGATTTAAAAGATTTCCCAAACGAGGTTCA
GCAAGTTGTGGGTTATGCCTTGTATATAGCTCAATGTGGAGACAAGCATCCTATTGCTAAGCCACTTAAAGGGTTTAAAG
GTGCTGGGGTTGTGGAAGTGGTAGATGACTTTGATGGAGATACTTATCGGGCAGTTTATACGATCAAATTTGCTGATGTT
GTTTATGTTTTGCATTCCTTTCAAAAGAAGTCGAAACAGGGCATTGCTACTCCAAAGCAAGATATGGATTTGATTGAAGC
AAGACTAAAACGCGCTAAAGAACATTACTCTGAGCATTACAACAAGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216107 WP_002916312.1 NZ_CP083070:837185-837451 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216107 NZ_CP112874:3453795-3454124 [Pseudanabaena galeata CCNP1313]
ATGACTGAAGAGATTAAGGTACAAAAAAGTAGTGGTAATGTATTTGCAGATTTGGGATTAGAGAATTCTGATGAGTTGCT
GGTTAAAGCAGAACTTGCTTACAAAATCAGCAGTATCATTACTAAGTTAGAAATAACTCAAGTTGAAGCGGCTAAGCTAT
TGGGAATCGATCAGCCTAAGATGTCGGCTTTGCTCAATGGCAAGTTATCAGGATTTTCGACTGTGAGGTTGTTTAGATTT
TTAAATTCTCTGGGTCGTGATGTGGAGATTGTAGTGAAAGATAAGCCTAAATCGCGTTCTCAGGCTCGTACTCAGGTTGT
GAGCAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References