Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5262500..5263125 Replicon chromosome
Accession NZ_CP083066
Organism Klebsiella pneumoniae strain 1613015451

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9F39_RS25795 Protein ID WP_094645114.1
Coordinates 5262500..5262883 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag K9F39_RS25800 Protein ID WP_004150355.1
Coordinates 5262883..5263125 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F39_RS25780 (5259866) 5259866..5260768 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
K9F39_RS25785 (5260765) 5260765..5261400 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
K9F39_RS25790 (5261397) 5261397..5262326 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
K9F39_RS25795 (5262500) 5262500..5262883 - 384 WP_094645114.1 type II toxin-antitoxin system VapC family toxin Toxin
K9F39_RS25800 (5262883) 5262883..5263125 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
K9F39_RS25805 (5263330) 5263330..5264247 + 918 WP_088497967.1 alpha/beta hydrolase -
K9F39_RS25810 (5264261) 5264261..5265202 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
K9F39_RS25815 (5265247) 5265247..5265684 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
K9F39_RS25820 (5265681) 5265681..5266541 - 861 WP_002882807.1 virulence factor BrkB family protein -
K9F39_RS25825 (5266535) 5266535..5267134 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14324.57 Da        Isoelectric Point: 6.7186

>T216100 WP_094645114.1 NZ_CP083066:c5262883-5262500 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGCREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T216100 NZ_CP112873:2275404-2275520 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT216100 WP_004150355.1 NZ_CP083066:c5263125-5262883 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT216100 NZ_CP112873:c2275694-2275515 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References