Detailed information of TA system TA021610

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /COG5642-COG5654
• Location: 1903475..1904441
• Replicon: chromosome
• Accession: NC_008150
• Organism: Yersinia pestis Antiqua

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E8XJV6
• Locus tag: YPA_RS08910
• Protein ID: WP_002210981.1
• Coordinates: 1903983..1904441 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E1NXA5
• Locus tag: YPA_RS08905
• Protein ID: WP_002220311.1
• Coordinates: 1903475..1903921 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
YPA_RS08885	1899065..1900039	-	975	WP_002210985.1	L-Ala-D/L-Glu epimerase	-
YPA_RS08890	1900202..1900705	+	504	WP_002210984.1	thiol peroxidase	-
YPA_RS08895	1900958..1901416	+	459	WP_002213775.1	IS200/IS605-like element IS1541B family transposase	-
YPA_RS08900	1901563..1903140	-	1578	WP_002210983.1	transcriptional regulator TyrR	-
YPA_RS08905	1903475..1903921	+	447	WP_002220311.1	DUF2384 domain-containing protein	Antitoxin
YPA_RS08910	1903983..1904441	+	459	WP_002210981.1	RES family NAD+ phosphorylase	Toxin
YPA_RS08915	1904451..1905512	-	1062	WP_002210980.1	YcjF family protein	-
YPA_RS08920	1905509..1906906	-	1398	WP_002210979.1	YcjX family protein	-
YPA_RS08925	1906887..1907129	-	243	WP_002216375.1	phage shock protein PspD	-
YPA_RS08930	1907214..1907573	-	360	WP_002210977.1	envelope stress response membrane protein PspC	-
YPA_RS08935	1907573..1907800	-	228	WP_002210976.1	envelope stress response membrane protein PspB	-
YPA_RS08940	1907962..1908627	-	666	WP_002210975.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1901171..1901416	245

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (2-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16994.38 Da
• Isoelectric Point: 4.8732

>T21610 WP_002210981.1 NC_008150:1903983-1904441 [Yersinia pestis Antiqua]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Nucleotide

• Length: 459 bp

>T21610 NC_008150:1903983-1904441 [Yersinia pestis Antiqua]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16332.83 Da
• Isoelectric Point: 9.0335

>AT21610 WP_002220311.1 NC_008150:1903475-1903921 [Yersinia pestis Antiqua]
MRAYRPNPATKMGTLWSEIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Nucleotide

• Length: 447 bp

>AT21610 NC_008150:1903475-1903921 [Yersinia pestis Antiqua]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGAGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Structures

Toxin

• AlphaFold DB: A0A0E8XJV6

Antitoxin

• AlphaFold DB: A0A0E1NXA5