Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4784651..4785167 Replicon chromosome
Accession NZ_CP083066
Organism Klebsiella pneumoniae strain 1613015451

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag K9F39_RS23520 Protein ID WP_094645165.1
Coordinates 4784651..4784935 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F39_RS23525 Protein ID WP_002886901.1
Coordinates 4784925..4785167 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F39_RS23495 (4780047) 4780047..4780310 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
K9F39_RS23500 (4780440) 4780440..4780613 + 174 WP_032408826.1 hypothetical protein -
K9F39_RS23505 (4780616) 4780616..4781359 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F39_RS23510 (4781716) 4781716..4783854 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F39_RS23515 (4784183) 4784183..4784647 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F39_RS23520 (4784651) 4784651..4784935 - 285 WP_094645165.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F39_RS23525 (4784925) 4784925..4785167 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F39_RS23530 (4785245) 4785245..4787155 - 1911 WP_009486549.1 PRD domain-containing protein -
K9F39_RS23535 (4787178) 4787178..4788332 - 1155 WP_004178372.1 lactonase family protein -
K9F39_RS23540 (4788399) 4788399..4789139 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11069.93 Da        Isoelectric Point: 10.4962

>T216098 WP_094645165.1 NZ_CP083066:c4784935-4784651 [Klebsiella pneumoniae]
MTYELEFDPRAWRGWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T216098 NZ_CP112873:c2221770-2221594 [Bacillus subtilis]
GTGCTTGAGAAAATGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCCGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT216098 WP_002886901.1 NZ_CP083066:c4785167-4784925 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216098 NZ_CP112873:2221553-2221653 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References