Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4080511..4081130 Replicon chromosome
Accession NZ_CP083066
Organism Klebsiella pneumoniae strain 1613015451

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F39_RS20160 Protein ID WP_002892050.1
Coordinates 4080912..4081130 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F39_RS20155 Protein ID WP_002892066.1
Coordinates 4080511..4080885 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F39_RS20145 (4075663) 4075663..4076856 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F39_RS20150 (4076879) 4076879..4080025 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F39_RS20155 (4080511) 4080511..4080885 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F39_RS20160 (4080912) 4080912..4081130 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F39_RS20165 (4081289) 4081289..4081855 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F39_RS20170 (4081827) 4081827..4081967 - 141 WP_004147370.1 hypothetical protein -
K9F39_RS20175 (4081988) 4081988..4082458 + 471 WP_002892026.1 YlaC family protein -
K9F39_RS20180 (4082433) 4082433..4083884 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K9F39_RS20185 (4083985) 4083985..4084683 + 699 WP_002892021.1 GNAT family protein -
K9F39_RS20190 (4084680) 4084680..4084820 - 141 WP_040245625.1 type B 50S ribosomal protein L36 -
K9F39_RS20195 (4084820) 4084820..4085083 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216096 WP_002892050.1 NZ_CP083066:4080912-4081130 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216096 NZ_CP112873:2071692-2071784 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216096 WP_002892066.1 NZ_CP083066:4080511-4080885 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216096 NZ_CP112873:c2071938-2071765 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References