Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1345859..1346505 Replicon chromosome
Accession NC_008150
Organism Yersinia pestis Antiqua

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPA_RS06305 Protein ID WP_002214976.1
Coordinates 1346323..1346505 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPA_RS06300 Protein ID WP_002211129.1
Coordinates 1345859..1346278 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPA_RS06280 1340930..1341925 + 996 WP_002211125.1 substrate-binding domain-containing protein -
YPA_RS06285 1341991..1343568 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
YPA_RS06290 1343571..1344593 + 1023 WP_002214974.1 ABC transporter permease -
YPA_RS06295 1344642..1345601 + 960 WP_002211128.1 sugar kinase -
YPA_RS06300 1345859..1346278 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YPA_RS06305 1346323..1346505 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
YPA_RS06310 1346712..1347494 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
YPA_RS06315 1347497..1347766 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
YPA_RS06320 1347872..1348612 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
YPA_RS06325 1348693..1349229 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
YPA_RS06330 1349229..1349645 - 417 WP_002211134.1 flagellar motor switch protein FliN -
YPA_RS06335 1349642..1350643 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
YPA_RS06340 1350649..1351119 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T21609 WP_002214976.1 NC_008150:c1346505-1346323 [Yersinia pestis Antiqua]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T21609 NC_008150:c1346505-1346323 [Yersinia pestis Antiqua]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT21609 WP_002211129.1 NC_008150:c1346278-1345859 [Yersinia pestis Antiqua]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT21609 NC_008150:c1346278-1345859 [Yersinia pestis Antiqua]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References