Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 800125..800782 Replicon chromosome
Accession NZ_CP083066
Organism Klebsiella pneumoniae strain 1613015451

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag K9F39_RS04025 Protein ID WP_002916310.1
Coordinates 800372..800782 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F39_RS04020 Protein ID WP_002916312.1
Coordinates 800125..800391 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F39_RS03995 (795281) 795281..796714 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
K9F39_RS04000 (796833) 796833..797561 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F39_RS04005 (797611) 797611..797922 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F39_RS04010 (798086) 798086..798745 + 660 WP_002916317.1 hemolysin III family protein -
K9F39_RS04015 (798896) 798896..799879 - 984 WP_094645172.1 tRNA-modifying protein YgfZ -
K9F39_RS04020 (800125) 800125..800391 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F39_RS04025 (800372) 800372..800782 + 411 WP_002916310.1 protein YgfX Toxin
K9F39_RS04030 (800789) 800789..801310 - 522 WP_004144730.1 flavodoxin FldB -
K9F39_RS04035 (801411) 801411..802307 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F39_RS04040 (802330) 802330..803044 + 715 Protein_792 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F39_RS04045 (803050) 803050..804783 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T216085 WP_002916310.1 NZ_CP083066:800372-800782 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216085 NZ_CP112862:494980-495321 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCAGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216085 WP_002916312.1 NZ_CP083066:800125-800391 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216085 NZ_CP112862:494750-494980 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References