Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4037575..4038194 Replicon chromosome
Accession NZ_CP083063
Organism Klebsiella pneumoniae strain 1613163991

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F41_RS19810 Protein ID WP_002892050.1
Coordinates 4037976..4038194 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F41_RS19805 Protein ID WP_002892066.1
Coordinates 4037575..4037949 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F41_RS19795 (4032727) 4032727..4033920 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F41_RS19800 (4033943) 4033943..4037089 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F41_RS19805 (4037575) 4037575..4037949 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F41_RS19810 (4037976) 4037976..4038194 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F41_RS19815 (4038353) 4038353..4038919 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F41_RS19820 (4038891) 4038891..4039031 - 141 WP_004147370.1 hypothetical protein -
K9F41_RS19825 (4039052) 4039052..4039522 + 471 WP_002892026.1 YlaC family protein -
K9F41_RS19830 (4039497) 4039497..4040948 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K9F41_RS19835 (4041049) 4041049..4041747 + 699 WP_002892021.1 GNAT family protein -
K9F41_RS19840 (4041744) 4041744..4041884 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F41_RS19845 (4041884) 4041884..4042147 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216078 WP_002892050.1 NZ_CP083063:4037976-4038194 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216078 NZ_CP111146:c1269590-1269300 [Pasteurella multocida]
ATGAGTAAAAAAGTAGAATTAAAACCATTTGATATTGCTGAATACCTAGATAGTGAAGAAATGATTGCGGCATATTTAAG
TGAAATTTTAGAAACAGGTGACACTAATGAATTTATTTCTGCGCTAGGTGATGTCGCAAGAGCGAGAGGAATGACGGAGT
TAGCGGCAAAAACAGGATTAGGAAGAGAAAGTCTCTATAAAACATTATCACACGGAAGTAAGCCGCGTTTTGATACTATA
ATGAAAATTACGCAAGCACTAGGTATTAAACTTGTCCCAACGCATATCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216078 WP_002892066.1 NZ_CP083063:4037575-4037949 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216078 NZ_CP111146:c1269901-1269587 [Pasteurella multocida]
ATGCTCGATATAATTGAAACAACAGTATTTAATAAATGGCTTAAAGAGCTAAAGGATTTGTCGGCTAAAGCGGCTATTCT
TGCACGTATTAGTCGCGCTAAAAGTGGTAATTTTGGTGACCATAAATCAGTTGGTGATGGTTTGTATGAAATGCGAATAA
TGAAAGGAGCTGGTTATAGGGTTTATTATGCACAATACAAAGATGTAACCTATTTGCTAATTTGTGGCGGTGATAAATCT
ACTCAGAAAGCAGATATCGCTAAAGCAAAAGCATTATGGGAAGAGATTAAGCAGAAAGAGGAGATAAATGTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References