Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 790961..791618 Replicon chromosome
Accession NZ_CP083055
Organism Klebsiella pneumoniae strain 1613258639

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag K9F40_RS03940 Protein ID WP_040245400.1
Coordinates 791208..791618 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag K9F40_RS03935 Protein ID WP_002916312.1
Coordinates 790961..791227 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F40_RS03910 (786117) 786117..787550 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
K9F40_RS03915 (787669) 787669..788397 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
K9F40_RS03920 (788447) 788447..788758 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
K9F40_RS03925 (788922) 788922..789581 + 660 WP_048334397.1 hemolysin III family protein -
K9F40_RS03930 (789732) 789732..790715 - 984 WP_032430613.1 tRNA-modifying protein YgfZ -
K9F40_RS03935 (790961) 790961..791227 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
K9F40_RS03940 (791208) 791208..791618 + 411 WP_040245400.1 protein YgfX Toxin
K9F40_RS03945 (791625) 791625..792146 - 522 WP_002916308.1 flavodoxin FldB -
K9F40_RS03950 (792247) 792247..793143 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
K9F40_RS03955 (793166) 793166..793879 + 714 WP_048290928.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9F40_RS03960 (793885) 793885..795618 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16035.83 Da        Isoelectric Point: 11.4778

>T216049 WP_040245400.1 NZ_CP083055:791208-791618 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216049 NZ_CP111115:2009292-2009395 [Raoultella sp. DY2415]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216049 WP_002916312.1 NZ_CP083055:790961-791227 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216049 NZ_CP111115:c2009400-2009234 [Raoultella sp. DY2415]
CAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGCGTCAGGTTTTCCAGTCCGCAACAAAAGTGGT
CGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References