Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5223469..5224094 | Replicon | chromosome |
Accession | NZ_CP083051 | ||
Organism | Klebsiella pneumoniae strain 0213293972 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | A0A483GDF6 |
Locus tag | K9F37_RS25755 | Protein ID | WP_004187928.1 |
Coordinates | 5223469..5223852 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | K9F37_RS25760 | Protein ID | WP_004150355.1 |
Coordinates | 5223852..5224094 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K9F37_RS25740 (5220835) | 5220835..5221737 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
K9F37_RS25745 (5221734) | 5221734..5222369 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
K9F37_RS25750 (5222366) | 5222366..5223295 | + | 930 | WP_004150358.1 | formate dehydrogenase accessory protein FdhE | - |
K9F37_RS25755 (5223469) | 5223469..5223852 | - | 384 | WP_004187928.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
K9F37_RS25760 (5223852) | 5223852..5224094 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
K9F37_RS25765 (5224288) | 5224288..5225205 | + | 918 | WP_004187929.1 | alpha/beta hydrolase | - |
K9F37_RS25770 (5225219) | 5225219..5226160 | - | 942 | WP_004178031.1 | fatty acid biosynthesis protein FabY | - |
K9F37_RS25775 (5226205) | 5226205..5226642 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
K9F37_RS25780 (5226639) | 5226639..5227499 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
K9F37_RS25785 (5227493) | 5227493..5228092 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14407.64 Da Isoelectric Point: 7.3178
>T216046 WP_004187928.1 NZ_CP083051:c5223852-5223469 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE
Download Length: 384 bp
>T216046 NZ_CP111114:5472384-5473028 [Pseudomonas koreensis]
ATGATCTATACCAACCTGAATCCAGAGAAAGCTCTGATTTGGCGTATCGTCCATCGCGATAACCTGCCCTGGATTCTGGA
CAACGGTCTGCATTGCGCAAACTCGGAAGCAAAGGCACCTCAGTACGTGAATATCGGCAACGTCGACTTGATCGACAAAC
GCCGTTTCCGTCAGGTGCCTATCGCACCCGAAGGCGTACTGGCCGACTACGTGCCCTTCTATTTCACACCCTTCTCGGTG
ATGATGCAGAACATTCACTCTGGCTGGAGTGTTCAACAACGCGGCAATGACGAGATCGTGATTCTGGTCTCAAGCCTCTA
TCGCGTTGAAGAGCTTGGCCTACCGTTTGTCTTCACAAACGCTCATGCCTACCCGAGTTGGACAAACTACTACAGCGATC
TGGCGAATCTCGACCAGATCGATTGGTCTATCCTTCAACGGCGCGACTTCAAGCGCGATCCTGACGACCCTCGCAAAATG
GAGCGTTATCAGGCTGAGGCGCTGATCCACCAACATTTACCGATTACGGGACTACTGGGCATCATGTGCCACACCGATGC
AATGAAAGTACGCATAGAAGCAGACGTGGCCGTTAGAGGCTTGACGTTGCCGGTCCATGCGCGTCCCAAATGGTATTTCC
AATGA
ATGATCTATACCAACCTGAATCCAGAGAAAGCTCTGATTTGGCGTATCGTCCATCGCGATAACCTGCCCTGGATTCTGGA
CAACGGTCTGCATTGCGCAAACTCGGAAGCAAAGGCACCTCAGTACGTGAATATCGGCAACGTCGACTTGATCGACAAAC
GCCGTTTCCGTCAGGTGCCTATCGCACCCGAAGGCGTACTGGCCGACTACGTGCCCTTCTATTTCACACCCTTCTCGGTG
ATGATGCAGAACATTCACTCTGGCTGGAGTGTTCAACAACGCGGCAATGACGAGATCGTGATTCTGGTCTCAAGCCTCTA
TCGCGTTGAAGAGCTTGGCCTACCGTTTGTCTTCACAAACGCTCATGCCTACCCGAGTTGGACAAACTACTACAGCGATC
TGGCGAATCTCGACCAGATCGATTGGTCTATCCTTCAACGGCGCGACTTCAAGCGCGATCCTGACGACCCTCGCAAAATG
GAGCGTTATCAGGCTGAGGCGCTGATCCACCAACATTTACCGATTACGGGACTACTGGGCATCATGTGCCACACCGATGC
AATGAAAGTACGCATAGAAGCAGACGTGGCCGTTAGAGGCTTGACGTTGCCGGTCCATGCGCGTCCCAAATGGTATTTCC
AATGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT216046 WP_004150355.1 NZ_CP083051:c5224094-5223852 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT216046 NZ_CP111114:5473025-5474110 [Pseudomonas koreensis]
ATGATCAGATTCACCCAAGGCAACCTGCTGGAAGCCAAAACTGAAGCGCTCGTCAACACGGTGAATACCGTGGGTGTAAT
GGGTAAGGGCATCGCACTGATGTTCAAGGAACGCTTTGCGCAGAATTACCGACTATATGCAGCCGCGTGCAAAGCCGGGG
ATGTCGAAACCGGCAAAATGCACGTGACTGCCACCAACGAACTCGATGGACCGCGCTGGATTGTGAATTTCCCCACCAAG
CGCCACTGGCGGTACCCGTCGCAAATGGCATGGATAACTGAAGGCTTGCATGATCTGCGACGGTTTCTGCTTGAAAACGA
TGTGAAGTCCGTCGCCGTTCCTCCGCTGGGCGCTGGTAACGGTGGTTTGAAGTGGCCTGAAGTGCGCGAGCAGATTGTAG
AAGTGCTCGGTGACTTGGATGTCGACGTATTAGTGTTCGAACCCTCCAGTCAGTATCTGAATGTCGCTAAGCGCGATGGC
GTTGAGCAACTCACTCCGGCACGCGCACTGATCGCTGAACTGGTCCGGCGTTATTGGGTTCTGGGCATGGAATGCAGCCT
GCTCGAAATTCAGAAACTGGCTTGGTTTCTTGAACGCGCAATCGAGAAAATTCCAGGTACTGAGAATCCGCTGAACCTCA
AATTTGTCGCTCATAAATTCGGCCCGTATGCCAATCGATTGGAGCATCTGCTGAACAATCTGGATGGCAGCTATCTACAT
TGCGACAAGCGCATCAGTGATGCTGGAATCACCGATGTCATTTGGTTTGATCAAGATCGCAAAACGTTTTTGCAGACCTA
CCTCAAGACCGAAGCTAAGGAATACTCTCAAGCTTTAGAGCGGACGGCTGAATTGATCGATGGTTTTGAGTCACCTTTCG
GCATGGAGTTGCTGGCGACCGTTGATTGGTTGCTGATTCGGGAAAGGATTGCTCCAACCGTTCCTGCGGTACGTAAAGCA
CTGATGAACTGGGACGGTGGGTCCGGAGCTGCGGTGCGTAAAAACAAATTATTCGATGATCAGGCACTAGGAATTGCGAT
CACGCGTCTGACATCCACCAGCTTCAGCCCGGAAATGGCGGCCTGA
ATGATCAGATTCACCCAAGGCAACCTGCTGGAAGCCAAAACTGAAGCGCTCGTCAACACGGTGAATACCGTGGGTGTAAT
GGGTAAGGGCATCGCACTGATGTTCAAGGAACGCTTTGCGCAGAATTACCGACTATATGCAGCCGCGTGCAAAGCCGGGG
ATGTCGAAACCGGCAAAATGCACGTGACTGCCACCAACGAACTCGATGGACCGCGCTGGATTGTGAATTTCCCCACCAAG
CGCCACTGGCGGTACCCGTCGCAAATGGCATGGATAACTGAAGGCTTGCATGATCTGCGACGGTTTCTGCTTGAAAACGA
TGTGAAGTCCGTCGCCGTTCCTCCGCTGGGCGCTGGTAACGGTGGTTTGAAGTGGCCTGAAGTGCGCGAGCAGATTGTAG
AAGTGCTCGGTGACTTGGATGTCGACGTATTAGTGTTCGAACCCTCCAGTCAGTATCTGAATGTCGCTAAGCGCGATGGC
GTTGAGCAACTCACTCCGGCACGCGCACTGATCGCTGAACTGGTCCGGCGTTATTGGGTTCTGGGCATGGAATGCAGCCT
GCTCGAAATTCAGAAACTGGCTTGGTTTCTTGAACGCGCAATCGAGAAAATTCCAGGTACTGAGAATCCGCTGAACCTCA
AATTTGTCGCTCATAAATTCGGCCCGTATGCCAATCGATTGGAGCATCTGCTGAACAATCTGGATGGCAGCTATCTACAT
TGCGACAAGCGCATCAGTGATGCTGGAATCACCGATGTCATTTGGTTTGATCAAGATCGCAAAACGTTTTTGCAGACCTA
CCTCAAGACCGAAGCTAAGGAATACTCTCAAGCTTTAGAGCGGACGGCTGAATTGATCGATGGTTTTGAGTCACCTTTCG
GCATGGAGTTGCTGGCGACCGTTGATTGGTTGCTGATTCGGGAAAGGATTGCTCCAACCGTTCCTGCGGTACGTAAAGCA
CTGATGAACTGGGACGGTGGGTCCGGAGCTGCGGTGCGTAAAAACAAATTATTCGATGATCAGGCACTAGGAATTGCGAT
CACGCGTCTGACATCCACCAGCTTCAGCCCGGAAATGGCGGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A483GDF6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |