Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5223469..5224094 Replicon chromosome
Accession NZ_CP083051
Organism Klebsiella pneumoniae strain 0213293972

Toxin (Protein)


Gene name vapC Uniprot ID A0A483GDF6
Locus tag K9F37_RS25755 Protein ID WP_004187928.1
Coordinates 5223469..5223852 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag K9F37_RS25760 Protein ID WP_004150355.1
Coordinates 5223852..5224094 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F37_RS25740 (5220835) 5220835..5221737 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
K9F37_RS25745 (5221734) 5221734..5222369 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
K9F37_RS25750 (5222366) 5222366..5223295 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
K9F37_RS25755 (5223469) 5223469..5223852 - 384 WP_004187928.1 type II toxin-antitoxin system VapC family toxin Toxin
K9F37_RS25760 (5223852) 5223852..5224094 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
K9F37_RS25765 (5224288) 5224288..5225205 + 918 WP_004187929.1 alpha/beta hydrolase -
K9F37_RS25770 (5225219) 5225219..5226160 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
K9F37_RS25775 (5226205) 5226205..5226642 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
K9F37_RS25780 (5226639) 5226639..5227499 - 861 WP_004146232.1 virulence factor BrkB family protein -
K9F37_RS25785 (5227493) 5227493..5228092 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14407.64 Da        Isoelectric Point: 7.3178

>T216046 WP_004187928.1 NZ_CP083051:c5223852-5223469 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFTGIPGVVTPYEIHPE

Download         Length: 384 bp

>T216046 NZ_CP111114:5472384-5473028 [Pseudomonas koreensis]
ATGATCTATACCAACCTGAATCCAGAGAAAGCTCTGATTTGGCGTATCGTCCATCGCGATAACCTGCCCTGGATTCTGGA
CAACGGTCTGCATTGCGCAAACTCGGAAGCAAAGGCACCTCAGTACGTGAATATCGGCAACGTCGACTTGATCGACAAAC
GCCGTTTCCGTCAGGTGCCTATCGCACCCGAAGGCGTACTGGCCGACTACGTGCCCTTCTATTTCACACCCTTCTCGGTG
ATGATGCAGAACATTCACTCTGGCTGGAGTGTTCAACAACGCGGCAATGACGAGATCGTGATTCTGGTCTCAAGCCTCTA
TCGCGTTGAAGAGCTTGGCCTACCGTTTGTCTTCACAAACGCTCATGCCTACCCGAGTTGGACAAACTACTACAGCGATC
TGGCGAATCTCGACCAGATCGATTGGTCTATCCTTCAACGGCGCGACTTCAAGCGCGATCCTGACGACCCTCGCAAAATG
GAGCGTTATCAGGCTGAGGCGCTGATCCACCAACATTTACCGATTACGGGACTACTGGGCATCATGTGCCACACCGATGC
AATGAAAGTACGCATAGAAGCAGACGTGGCCGTTAGAGGCTTGACGTTGCCGGTCCATGCGCGTCCCAAATGGTATTTCC
AATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT216046 WP_004150355.1 NZ_CP083051:c5224094-5223852 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT216046 NZ_CP111114:5473025-5474110 [Pseudomonas koreensis]
ATGATCAGATTCACCCAAGGCAACCTGCTGGAAGCCAAAACTGAAGCGCTCGTCAACACGGTGAATACCGTGGGTGTAAT
GGGTAAGGGCATCGCACTGATGTTCAAGGAACGCTTTGCGCAGAATTACCGACTATATGCAGCCGCGTGCAAAGCCGGGG
ATGTCGAAACCGGCAAAATGCACGTGACTGCCACCAACGAACTCGATGGACCGCGCTGGATTGTGAATTTCCCCACCAAG
CGCCACTGGCGGTACCCGTCGCAAATGGCATGGATAACTGAAGGCTTGCATGATCTGCGACGGTTTCTGCTTGAAAACGA
TGTGAAGTCCGTCGCCGTTCCTCCGCTGGGCGCTGGTAACGGTGGTTTGAAGTGGCCTGAAGTGCGCGAGCAGATTGTAG
AAGTGCTCGGTGACTTGGATGTCGACGTATTAGTGTTCGAACCCTCCAGTCAGTATCTGAATGTCGCTAAGCGCGATGGC
GTTGAGCAACTCACTCCGGCACGCGCACTGATCGCTGAACTGGTCCGGCGTTATTGGGTTCTGGGCATGGAATGCAGCCT
GCTCGAAATTCAGAAACTGGCTTGGTTTCTTGAACGCGCAATCGAGAAAATTCCAGGTACTGAGAATCCGCTGAACCTCA
AATTTGTCGCTCATAAATTCGGCCCGTATGCCAATCGATTGGAGCATCTGCTGAACAATCTGGATGGCAGCTATCTACAT
TGCGACAAGCGCATCAGTGATGCTGGAATCACCGATGTCATTTGGTTTGATCAAGATCGCAAAACGTTTTTGCAGACCTA
CCTCAAGACCGAAGCTAAGGAATACTCTCAAGCTTTAGAGCGGACGGCTGAATTGATCGATGGTTTTGAGTCACCTTTCG
GCATGGAGTTGCTGGCGACCGTTGATTGGTTGCTGATTCGGGAAAGGATTGCTCCAACCGTTCCTGCGGTACGTAAAGCA
CTGATGAACTGGGACGGTGGGTCCGGAGCTGCGGTGCGTAAAAACAAATTATTCGATGATCAGGCACTAGGAATTGCGAT
CACGCGTCTGACATCCACCAGCTTCAGCCCGGAAATGGCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483GDF6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References