Detailed information of TA system TA216045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4901191..4902872
• Replicon: chromosome
• Accession: NZ_CP083051
• Organism: Klebsiella pneumoniae strain 0213293972

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A486LFH0
• Locus tag: K9F37_RS24270
• Protein ID: WP_023328808.1
• Coordinates: 4901191..4902108 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A0A486Q3T7
• Locus tag: K9F37_RS24275
• Protein ID: WP_023328807.1
• Coordinates: 4902114..4902872 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F37_RS24250 (4896497)	4896497..4898017	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
K9F37_RS24255 (4898014)	4898014..4899012	+	999	WP_031592479.1	ribose ABC transporter permease	-
K9F37_RS24260 (4899043)	4899043..4899984	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
K9F37_RS24265 (4900059)	4900059..4901066	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
K9F37_RS24270 (4901191)	4901191..4902108	-	918	WP_023328808.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
K9F37_RS24275 (4902114)	4902114..4902872	-	759	WP_023328807.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
K9F37_RS24280 (4902958)	4902958..4903686	-	729	WP_002885152.1	response regulator transcription factor	-
K9F37_RS24285 (4903959)	4903959..4906106	+	2148	WP_077598921.1	formate dehydrogenase subunit alpha	-
K9F37_RS24290 (4906336)	4906336..4907022	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34660.13 Da
• Isoelectric Point: 5.4707

>T216045 WP_023328808.1 NZ_CP083051:c4902108-4901191 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T216045 NZ_CP111114:c3433137-3432856 [Pseudomonas koreensis]
ATGACCTATGAGCTGGAGTTTTCCGAGAAAGCCTGGAGGGAATGGAGAAAGCTTGATTCAGCACTTCAGGATCAGTTCAA
GAAAAAGCTCTCTACACGTCTGGTCAATCCTCACGTTCCTGCCGATCGACTCCGAGGGTTGGGAAACGCCTACAAAATCA
AGCTTCGCAGTGCTGGATACAGGCTGGTCTATCGCGTAAAGAACGAGGTTTTGGTTGTTACCGTGATTGCGGTAGGGAGA
AGAGAGCGGGGAGAGGTCTACGACAAAGCCGCTTGCCGATAG

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28582.94 Da
• Isoelectric Point: 10.0870

>AT216045 WP_023328807.1 NZ_CP083051:c4902872-4902114 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTFSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT216045 NZ_CP111114:c3433375-3433127 [Pseudomonas koreensis]
ATGACTCACGTAGTTCTTTCCAATATCGTTGCGAGTATTTCTGAATTGAAAAGAAACCCCATGGGTACCGTGGCCGCCGG
TGGCGGCCAATCTGTTGCAATCCTCAATCGAAATGAGCCAGCGTTTTATTGTGTTCCCGCAAAGGAGTATGAGGCGATGA
TGAATCGCCTTGAGGATCTGGAACTGATCGCACTGTGCAAGGAGCGAGAAAACGATCCCACCATCAAGGTCTCTATAGAT
GACCTATGA

Structures

Toxin

• AlphaFold DB: A0A486LFH0

Antitoxin

• AlphaFold DB: A0A486Q3T7