Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4736672..4737188 | Replicon | chromosome |
| Accession | NZ_CP083051 | ||
| Organism | Klebsiella pneumoniae strain 0213293972 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | R4YAY3 |
| Locus tag | K9F37_RS23440 | Protein ID | WP_004178374.1 |
| Coordinates | 4736672..4736956 (-) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | R4Y888 |
| Locus tag | K9F37_RS23445 | Protein ID | WP_002886901.1 |
| Coordinates | 4736946..4737188 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F37_RS23415 (4732156) | 4732156..4732419 | - | 264 | WP_014908078.1 | PTS sugar transporter subunit IIB | - |
| K9F37_RS23420 (4732549) | 4732549..4732722 | + | 174 | WP_019725541.1 | hypothetical protein | - |
| K9F37_RS23425 (4732725) | 4732725..4733468 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
| K9F37_RS23430 (4733825) | 4733825..4735963 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
| K9F37_RS23435 (4736204) | 4736204..4736668 | + | 465 | WP_004222151.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
| K9F37_RS23440 (4736672) | 4736672..4736956 | - | 285 | WP_004178374.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9F37_RS23445 (4736946) | 4736946..4737188 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K9F37_RS23450 (4737266) | 4737266..4739176 | - | 1911 | WP_031593171.1 | PRD domain-containing protein | - |
| K9F37_RS23455 (4739199) | 4739199..4740353 | - | 1155 | WP_002886900.1 | lactonase family protein | - |
| K9F37_RS23460 (4740420) | 4740420..4741160 | - | 741 | WP_004186692.1 | KDGP aldolase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11155.97 Da Isoelectric Point: 10.3787
>T216044 WP_004178374.1 NZ_CP083051:c4736956-4736672 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T216044 NZ_CP111114:c2833001-2832411 [Pseudomonas koreensis]
ATGAACCTCGAAATGATCAAAGGCCGCCTCGAATTCCTGCGCGAAGCAGAAAAACTCAAGGACGTGCTGCGCAGCGCGCA
CACCTCCAGCGGCCGCACCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATTGTCTTCGCCGATCAAC
TGGCCGGCCTCGACCTGCTCAAGGTCCTGAAGATGTGCGTGATTCACGATTTGGGCGAAGCCATCAATGGTGACATTCCA
GCGGTCAATCAGGCCGCGTTCCCCGACAAGGGTGAACAGGAACGCAACGACCTTCTGCTGCTGACCGGTGCGCTCGATGA
GGCGCTGCGCAGCGAAATTCTAGCGCTGTGGGACGACTACGAAAATGCTCAGTCCGCCGAAGCCAAAGCGGTCAAGGCAC
TGGATAAACTGGAGACGCTGCTGCAACACAACCAGGGGCTGAACCCGGCGGATTTCGATTACGGTTTCAATCTGGGCTAC
GGCAAGAAATACACCAGTGCCGACCCGGTCTTCGCCACCCTGCGTGAGCTGATCGACCAAGACACGCAACAGCGCATCAG
CGACGGCCAAAACAGCAACGAGCGATCCTGA
ATGAACCTCGAAATGATCAAAGGCCGCCTCGAATTCCTGCGCGAAGCAGAAAAACTCAAGGACGTGCTGCGCAGCGCGCA
CACCTCCAGCGGCCGCACCGAAAGCACCGCCGAACACAGCTGGCGCCTGTGCCTGATGGCGATTGTCTTCGCCGATCAAC
TGGCCGGCCTCGACCTGCTCAAGGTCCTGAAGATGTGCGTGATTCACGATTTGGGCGAAGCCATCAATGGTGACATTCCA
GCGGTCAATCAGGCCGCGTTCCCCGACAAGGGTGAACAGGAACGCAACGACCTTCTGCTGCTGACCGGTGCGCTCGATGA
GGCGCTGCGCAGCGAAATTCTAGCGCTGTGGGACGACTACGAAAATGCTCAGTCCGCCGAAGCCAAAGCGGTCAAGGCAC
TGGATAAACTGGAGACGCTGCTGCAACACAACCAGGGGCTGAACCCGGCGGATTTCGATTACGGTTTCAATCTGGGCTAC
GGCAAGAAATACACCAGTGCCGACCCGGTCTTCGCCACCCTGCGTGAGCTGATCGACCAAGACACGCAACAGCGCATCAG
CGACGGCCAAAACAGCAACGAGCGATCCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT216044 WP_002886901.1 NZ_CP083051:c4737188-4736946 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT216044 NZ_CP111114:c2833636-2833079 [Pseudomonas koreensis]
ATGTCAGACCTGTTATTGAAGCCCGCCCTGCCCGGTATCGCCCTGCGACGCTGGCGCCTGCTGCATCGCGTCAAACAGAC
TCACGCGGCGCAGTTGTTCAACGTCACCCAGTCGACCATTTCCCGCTGGGAAAGCGGTGTGCAGGCGATGGAACCTGCCG
CGCAACTGCAACTGGAGCGTTTGCTGACTGCGCGCCTGGACAGCGCCGCCGATCAGGTCTTGGCGCGTCTGATCGGGGAA
AGTCAGCGGCCGATGCACCTGATCTGCGACCTCACCCATCGCCTGCTGGCCTGCTCTCCTGCGCGTGCTGCCGAGTTCAC
CCGACCCTTGAGTACGTTGCTGGGACAATCGCTGTGGCGCTTCGCAACGCCGGAAATTGTGCTGAGAGAGTCGGCGCTGG
CAACCAGCGGTTGGCACGAAGTTCAGGCGCCGCCAGCCGTGGAATTCAGCACCGGCAGCAATGCCTCCGACCTCGTGCCG
ATCCGCGCCGGCCGATGCCGCTGGACGCGCATTCCACTCTCCGACGGCAGCGCCGCGCGGCTGGTGGAAACCCTCTGA
ATGTCAGACCTGTTATTGAAGCCCGCCCTGCCCGGTATCGCCCTGCGACGCTGGCGCCTGCTGCATCGCGTCAAACAGAC
TCACGCGGCGCAGTTGTTCAACGTCACCCAGTCGACCATTTCCCGCTGGGAAAGCGGTGTGCAGGCGATGGAACCTGCCG
CGCAACTGCAACTGGAGCGTTTGCTGACTGCGCGCCTGGACAGCGCCGCCGATCAGGTCTTGGCGCGTCTGATCGGGGAA
AGTCAGCGGCCGATGCACCTGATCTGCGACCTCACCCATCGCCTGCTGGCCTGCTCTCCTGCGCGTGCTGCCGAGTTCAC
CCGACCCTTGAGTACGTTGCTGGGACAATCGCTGTGGCGCTTCGCAACGCCGGAAATTGTGCTGAGAGAGTCGGCGCTGG
CAACCAGCGGTTGGCACGAAGTTCAGGCGCCGCCAGCCGTGGAATTCAGCACCGGCAGCAATGCCTCCGACCTCGTGCCG
ATCCGCGCCGGCCGATGCCGCTGGACGCGCATTCCACTCTCCGACGGCAGCGCCGCGCGGCTGGTGGAAACCCTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A6THG1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GLP0 |