Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yfjZ-ypjF/CbtA-CbeA |
| Location | 4650431..4651101 | Replicon | chromosome |
| Accession | NZ_CP083051 | ||
| Organism | Klebsiella pneumoniae strain 0213293972 | ||
Toxin (Protein)
| Gene name | ypjF | Uniprot ID | A0A483GLH7 |
| Locus tag | K9F37_RS23050 | Protein ID | WP_023301398.1 |
| Coordinates | 4650431..4650763 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A483GII7 |
| Locus tag | K9F37_RS23055 | Protein ID | WP_023301397.1 |
| Coordinates | 4650784..4651101 (-) | Length | 106 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9F37_RS23025 (4645656) | 4645656..4646328 | + | 673 | Protein_4516 | DUF4400 domain-containing protein | - |
| K9F37_RS23030 (4646339) | 4646339..4647223 | + | 885 | WP_004192285.1 | RES domain-containing protein | - |
| K9F37_RS23035 (4647422) | 4647422..4647610 | - | 189 | Protein_4518 | transposase | - |
| K9F37_RS23040 (4647627) | 4647627..4648738 | - | 1112 | Protein_4519 | IS3 family transposase | - |
| K9F37_RS23045 (4649137) | 4649137..4649997 | - | 861 | WP_023301399.1 | hypothetical protein | - |
| K9F37_RS23050 (4650431) | 4650431..4650763 | - | 333 | WP_023301398.1 | TA system toxin CbtA family protein | Toxin |
| K9F37_RS23055 (4650784) | 4650784..4651101 | - | 318 | WP_023301397.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| K9F37_RS23060 (4651120) | 4651120..4651341 | - | 222 | WP_023301396.1 | DUF987 domain-containing protein | - |
| K9F37_RS23065 (4651350) | 4651350..4651832 | - | 483 | WP_023301395.1 | RadC family protein | - |
| K9F37_RS23070 (4651841) | 4651841..4652299 | - | 459 | WP_023301394.1 | antirestriction protein | - |
| K9F37_RS23075 (4652385) | 4652385..4652621 | - | 237 | WP_032446575.1 | DUF905 domain-containing protein | - |
| K9F37_RS23080 (4652699) | 4652699..4653109 | - | 411 | WP_023301393.1 | hypothetical protein | - |
| K9F37_RS23085 (4653176) | 4653176..4653613 | - | 438 | WP_023301392.1 | hypothetical protein | - |
| K9F37_RS23090 (4653655) | 4653655..4654191 | - | 537 | WP_023301391.1 | DUF4339 domain-containing protein | - |
| K9F37_RS23095 (4654217) | 4654217..4654927 | - | 711 | WP_023301390.1 | DeoR family transcriptional regulator | - |
| K9F37_RS23100 (4655136) | 4655136..4655960 | - | 825 | WP_023301389.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12610.65 Da Isoelectric Point: 5.6692
>T216043 WP_023301398.1 NZ_CP083051:c4650763-4650431 [Klebsiella pneumoniae]
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
MKTLPATTPQTAKLCLTSADTWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGIPLADAVNFLVDKYALVRIDRRGL
SWQEQSSYLRLVDTQRTIKVIELWLFGVMM
Download Length: 333 bp
>T216043 NZ_CP111114:c2425097-2424747 [Pseudomonas koreensis]
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
TCAATTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTCAGCG
ACCAACGAAGAGGGAAAGGCAAGCGCAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTTCAACAAAAACGAGCAGGACGATTTGACGCCTGCCCAGAAAAAGCTTTTCAGAAAAACACTGGATAGAGA
ACTCAACGCGAGAAGCCACTATGAAACGTGA
ATGGATGCTCTATTTATCGAATTGCCTGTGTTTCAGAAGCACCGAGACGACTATCTGGATGACGATCTGTTTCGCAGCTT
TCAATTGGAGTTGCTGAAAAATCCGGAAGCGGGCGATCTCATCGAGGACACAGGCGGGCTTCGTAAAATTCGCTTCAGCG
ACCAACGAAGAGGGAAAGGCAAGCGCAGCGGATTACGAGTGATTTATTACTGGTGGTCAGGCTTCGATCAGTTCTGGCTC
TTTACCGTCTTCAACAAAAACGAGCAGGACGATTTGACGCCTGCCCAGAAAAAGCTTTTCAGAAAAACACTGGATAGAGA
ACTCAACGCGAGAAGCCACTATGAAACGTGA
Antitoxin
Download Length: 106 a.a. Molecular weight: 11785.37 Da Isoelectric Point: 6.6277
>AT216043 WP_023301397.1 NZ_CP083051:c4651101-4650784 [Klebsiella pneumoniae]
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
MSNITWGLQRDITPCLGSRLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSSGYVYIAVYLTQR
Download Length: 318 bp
>AT216043 NZ_CP111114:c2424757-2424443 [Pseudomonas koreensis]
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCATAAGGTTCAGCTGCCAAAACTGATGCCGATCACTGCTGAGGAAGTGATAGCCATCCGTCAGCAACTTAATCTTT
CCCGGTCAGTTTTCGCGATGTATCTACGCACCAATACGCGAACGCTCGAGAACTGGGAGCAAGGACGAGCTACGCCCAAT
GCTCAGGCCACAACCCTGATCCGTCTGGTCGAGCGTTTTCCACAGACAATCGAACAACTCGCAGCCCTGACCTGA
ATGAAACGTGACATTTTTTCCGAACTGATGGATGGACTGGAAGCACTGGCCGATGAACGCCAAGGCAAAATCACCTTGCG
TACCCATAAGGTTCAGCTGCCAAAACTGATGCCGATCACTGCTGAGGAAGTGATAGCCATCCGTCAGCAACTTAATCTTT
CCCGGTCAGTTTTCGCGATGTATCTACGCACCAATACGCGAACGCTCGAGAACTGGGAGCAAGGACGAGCTACGCCCAAT
GCTCAGGCCACAACCCTGATCCGTCTGGTCGAGCGTTTTCCACAGACAATCGAACAACTCGCAGCCCTGACCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GLH7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A483GII7 |