Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3996643..3997262 Replicon chromosome
Accession NZ_CP083051
Organism Klebsiella pneumoniae strain 0213293972

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F37_RS19870 Protein ID WP_002892050.1
Coordinates 3997044..3997262 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F37_RS19865 Protein ID WP_002892066.1
Coordinates 3996643..3997017 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F37_RS19855 (3991795) 3991795..3992988 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F37_RS19860 (3993011) 3993011..3996157 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F37_RS19865 (3996643) 3996643..3997017 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F37_RS19870 (3997044) 3997044..3997262 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F37_RS19875 (3997425) 3997425..3997991 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F37_RS19880 (3997963) 3997963..3998103 - 141 WP_004147370.1 hypothetical protein -
K9F37_RS19885 (3998124) 3998124..3998594 + 471 WP_002892026.1 YlaC family protein -
K9F37_RS19890 (3998569) 3998569..4000020 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
K9F37_RS19895 (4000121) 4000121..4000819 + 699 WP_002892021.1 GNAT family protein -
K9F37_RS19900 (4000816) 4000816..4000956 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F37_RS19905 (4000956) 4000956..4001219 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216041 WP_002892050.1 NZ_CP083051:3997044-3997262 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216041 NZ_CP111114:354074-354229 [Pseudomonas koreensis]
TTGAAAGCCCAAGGCGTTGAGTTTCAAACCGGCAAGGGCGGTCACTTCAAGGTTTCCTTGAATGGCAAATCAACTGTGTT
TCCCGACCATGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAATCGATAATCAAGCAGCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216041 WP_002892066.1 NZ_CP083051:3996643-3997017 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216041 NZ_CP111114:354260-354685 [Pseudomonas koreensis]
ATGTTCGAATATGCGTTGGAAGTTCACGAAGAGCCGGGCAGTGTCTGGCTGACCTGCGCAGAAATTCCTGAGATGCACGC
CGTTGGCGACACCCTCGAGCAAGCGTTGGACACCGCCATTGATGCAATCGAGACGGCGCTCTCGATATACGTTGATGATC
GCCGGTTGATTCCGACCGGGCAGGCAGGAGAACAGGCAAGTGGCGTCGTATTGCGTCTGCCTGCGCTGACTGCAGCAAAG
GTTGCTCTGTGGAATACGCTTTTGGAGTCAGGTTTAAGCAAGGCCGAGTTGGCACGTCGTCTCCGCGTACAACGGCCTCA
GGTCGATCGCCTGGTAGATTTCCTGCATCACTCCAAAATCGAGAATGTTGAGCGTGCGTTGCAGCAACTTGGAAGGCGGA
TTTCGCTTTCGGTTCAAGCTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References