Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 3996643..3997262 | Replicon | chromosome |
Accession | NZ_CP083051 | ||
Organism | Klebsiella pneumoniae strain 0213293972 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | K9F37_RS19870 | Protein ID | WP_002892050.1 |
Coordinates | 3997044..3997262 (+) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | K9F37_RS19865 | Protein ID | WP_002892066.1 |
Coordinates | 3996643..3997017 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K9F37_RS19855 (3991795) | 3991795..3992988 | + | 1194 | WP_004177236.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
K9F37_RS19860 (3993011) | 3993011..3996157 | + | 3147 | WP_002892069.1 | multidrug efflux RND transporter permease subunit AcrB | - |
K9F37_RS19865 (3996643) | 3996643..3997017 | + | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
K9F37_RS19870 (3997044) | 3997044..3997262 | + | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
K9F37_RS19875 (3997425) | 3997425..3997991 | + | 567 | WP_002892030.1 | maltose O-acetyltransferase | - |
K9F37_RS19880 (3997963) | 3997963..3998103 | - | 141 | WP_004147370.1 | hypothetical protein | - |
K9F37_RS19885 (3998124) | 3998124..3998594 | + | 471 | WP_002892026.1 | YlaC family protein | - |
K9F37_RS19890 (3998569) | 3998569..4000020 | - | 1452 | WP_002892023.1 | PLP-dependent aminotransferase family protein | - |
K9F37_RS19895 (4000121) | 4000121..4000819 | + | 699 | WP_002892021.1 | GNAT family protein | - |
K9F37_RS19900 (4000816) | 4000816..4000956 | - | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
K9F37_RS19905 (4000956) | 4000956..4001219 | - | 264 | WP_002892011.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T216041 WP_002892050.1 NZ_CP083051:3997044-3997262 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T216041 NZ_CP111114:354074-354229 [Pseudomonas koreensis]
TTGAAAGCCCAAGGCGTTGAGTTTCAAACCGGCAAGGGCGGTCACTTCAAGGTTTCCTTGAATGGCAAATCAACTGTGTT
TCCCGACCATGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAATCGATAATCAAGCAGCTGGGCCTCAAGGATTGA
TTGAAAGCCCAAGGCGTTGAGTTTCAAACCGGCAAGGGCGGTCACTTCAAGGTTTCCTTGAATGGCAAATCAACTGTGTT
TCCCGACCATGGAGCCAAGGAAATGGGCGAAGGGTTGAGAAAATCGATAATCAAGCAGCTGGGCCTCAAGGATTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT216041 WP_002892066.1 NZ_CP083051:3996643-3997017 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT216041 NZ_CP111114:354260-354685 [Pseudomonas koreensis]
ATGTTCGAATATGCGTTGGAAGTTCACGAAGAGCCGGGCAGTGTCTGGCTGACCTGCGCAGAAATTCCTGAGATGCACGC
CGTTGGCGACACCCTCGAGCAAGCGTTGGACACCGCCATTGATGCAATCGAGACGGCGCTCTCGATATACGTTGATGATC
GCCGGTTGATTCCGACCGGGCAGGCAGGAGAACAGGCAAGTGGCGTCGTATTGCGTCTGCCTGCGCTGACTGCAGCAAAG
GTTGCTCTGTGGAATACGCTTTTGGAGTCAGGTTTAAGCAAGGCCGAGTTGGCACGTCGTCTCCGCGTACAACGGCCTCA
GGTCGATCGCCTGGTAGATTTCCTGCATCACTCCAAAATCGAGAATGTTGAGCGTGCGTTGCAGCAACTTGGAAGGCGGA
TTTCGCTTTCGGTTCAAGCTGCATAA
ATGTTCGAATATGCGTTGGAAGTTCACGAAGAGCCGGGCAGTGTCTGGCTGACCTGCGCAGAAATTCCTGAGATGCACGC
CGTTGGCGACACCCTCGAGCAAGCGTTGGACACCGCCATTGATGCAATCGAGACGGCGCTCTCGATATACGTTGATGATC
GCCGGTTGATTCCGACCGGGCAGGCAGGAGAACAGGCAAGTGGCGTCGTATTGCGTCTGCCTGCGCTGACTGCAGCAAAG
GTTGCTCTGTGGAATACGCTTTTGGAGTCAGGTTTAAGCAAGGCCGAGTTGGCACGTCGTCTCCGCGTACAACGGCCTCA
GGTCGATCGCCTGGTAGATTTCCTGCATCACTCCAAAATCGAGAATGTTGAGCGTGCGTTGCAGCAACTTGGAAGGCGGA
TTTCGCTTTCGGTTCAAGCTGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |